Principal Scientist

Job Description

Principal Scientist - US, Lenexa, Kansas (KS)- LBA Method Development Team

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

Are you a scientist with expertise in method development? Take the next step in your career by joining ICON where you’ll advance groundbreaking clinical therapies by leading global client programs.

We are excited to be seeking a new Principal Scientist at ICON in Lenexa, Kansas (KS). The Principal Scientist will lead and conduct scientific research aimed at advancing clinical trials and developing innovative therapies. You will manage sponsor programs, shape assay strategies, and provide expertise for new and complex modalities.

We are seeking candidates with robust method development and knowledge in science for new biological modalities.

What You Will Do

This Research Scientist is responsible for method development and validation testing using complex ligand-binding analytical methods. In addition, you will oversee transfer of LBA methods for large molecules for further bioanalytical testing.

Desired Experience (ligand binding experience required)

• Ligand binding assays
  • ELISA, ECLIA
  • PK, PD, and immunogenicity
  • Usage of relevant software (e.g. Soft Max Pro, Watson, or equivalent)
• Neutralizing antibody or Flow Cytometry experience is beneficial.

Method Development

• Designs and executes experiments for method development under supervision or independently depending on level
• Develops new scientific approaches to method development and communicates these to the global science team
• Depending on level the scientist may:
  • Mentor more junior scientists and advise operation on developed methods
  • Reviews and approves data of other scientists
  • Communicate with team members and management regarding project status, purpose, scheduling, problems, etc.
  • Communicate and/or participate in communication with clients regarding project status.

Scientific

• Maintain knowledge and skill in all techniques where you perform your work.
• Provide scientific input to management and BD about new technology investments and lines of service.
• Discusses scientific results with sponsors together with project manager
• Promotes ICON utilizing their scientific skills through scientific communication such as external publication of posters and journal articles.
• Perform R&D projects
• Training of technicians on technical aspects
• Mentor and train staff on scientific topics

Quality and Timely Work Execution

• Takes initiative in process development and SOP/WI writing
• Legible, logical and reproducible documentation of all experimentation
• Has a thorough understanding and complies with GLP and other appropriate regulations
• Develops rugged and economical assays
• Performs data review of other scientist’s work

Sample Analysis and Assay Validation

• Provides key assay input to the validation and bioanalysis team(s) to ensure successful execution
• Assay troubleshooting
• May perform and document maintenance, troubleshooting and repairs on advanced instrumentation with support of service engineers or other trained supervisory personnel.

Qualifications

• Read, write and speak fluent English.
• BS in a scientific discipline required. Advanced degree (MS or PhD), preferred.
• 5 – 10 years of industry or academic laboratory experience supporting ligand-binding assays.
• Demonstrated method development experience within the clinical or pharmaceutical industry with a track record of managing scientific projects.
• Presenter/Publisher in Regulated relevant field, nice to have.

#LI-KM3

Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

Rewards & Benefits

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits may include:

• Competitive base salary and performance related incentives
• Health and wellbeing programmes including medical, dental, and vision coverage where applicable
• Retirement and pension plans
• Life assura