Chemist - Process Translation and Execution Lilly Medicine Foundry

The Process Translation and Execution (PTE) team translates API/DS process knowledge into clinical supply readiness and oversees technology transfer. In this role, the Chemist will facilitate the transfer of chemical processes from development laboratories to pilot plant operations (including kilohood or larger-scale production) to support early-phase cGMP manufacturing of kilogram quantities of API required for clinical trial supply.

• Actively involved in receiving chemistry from early phase process research and development labs and evaluating the safety of the incoming procedures in collaboration with the safety group and process engineering.
• Ordering and staging chemicals.
• Obtain reference materials and participate in setting up analytical methods.
• Reprocess and analyze analytical data to make fact‑based decisions.
• Efficient with summarizing and presenting chemistry results and challenges.
• Perform familiarization reactions to ensure plant readiness of process steps including chemical reactions, distillations, extractions, and crystallization/isolations at the Lilly Medicine Foundry.
• Perform use‑tests of key raw materials and document Definitive Lab Trials of processes to confirm plant readiness.
• Maintain a well‑organized and detailed lab notebook with accurate descriptions of the chemistry, observations, and organized analytical data to enable the preparation of technical packages/technical transfers and accurate replication in receiving labs.
• Documentation:
  Author, review technical documents, including tech transfer plan, standard operating procedures (SOPs), batch records, campaign summary reports, and deviation reports.
• Process improvement:
  Apply scientific knowledge to identify areas for improvement and implement new technologies or procedures.
• Contribute to process troubleshooting and investigations by supporting process deviations, quality events, and non‑conformances. Collaborate with teams to perform root cause analysis (RCA) and develop effective corrective and preventive actions (CAPAs).

• B.S. or M.S. in chemistry, chemical engineering, or related field.
• 2+ years of experience in manufacturing environments involving synthetic small molecule API or drug substance, or fine chemical synthesis is preferred.
• Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role.

• Working knowledge of organic chemistry and mechanisms and application to reaction improvement and optimization.
• Experience with synthetic chemistry techniques used for developing and scaling‑up chemical reactions. Experience using process chemistry concepts is a plus.
• Proficiency with the purification of chemicals via extraction, crystallization, chromatography, and distillation.
• Comfortable working with larger sized glass equipment.
• Highly motivated, able to learn rapidly, and demonstrates strong attention to detail.
• Has experience creating batch records and conducting scale‑up experiments according to those records.
• Ability to prioritize multiple activities and manage ambiguity.
• Experience with a variety of analytical techniques: HPLC/UPLC, LC‑MS, GC, NMR, IR, KF, XRPD, etc.
• Process quantification and acquiring mass balance for products and by‑products.
• Demonstrated ability to drive projects and accept change.
• Communication skills:
  Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams.
• Familiarity with crystallization and understanding of polymorphism and particle size control, and safe handling of solids/dry end processing.
• Problem‑solving skills:
  Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges.
• Ability to work cross‑functionally across disciplines and levels with engineers, analytical chemists, chemical technicians, safety and quality representatives.

• Initial location at Lilly Technology Center, Indianapolis.
• Permanent location at the new Lilly Medicines Foundry in Lebanon, Indiana.
• Limited domestic and…