Principal Process Engineer - Purification, Lilly Medicine Foundry

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.

Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first‑ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact.

Lilly is currently constructing an advanced research facility for production of API molecules for clinical trials located in Lebanon, IN. This facility is Lilly’s largest investment in a clinical trial manufacturing capacity and is intended to provide APIs for current and future products, including new modalities. This is a unique opportunity to be a part of the startup team for a greenfield manufacturing site, and the successful candidate will help to build the processes and facility to enable a successful startup into GMP manufacturing operations.

We are seeking experienced Process Engineers to support purification of biologics, peptides, oligonucleotides, and bioconjugates. This position involves solving technical challenges with equipment design, developing and sustaining process knowledge, optimizing processes, and managing equipment capabilities.

The Principal Process Engineer provides technical assessment and support for production operations in the areas of developing and sustaining process knowledge, process and equipment support, process optimization, equipment capability and asset management, and engineering business systems. In addition, the principal process engineer is expected to mentor newer engineers, drive cross-functional discussions, and proactively solve problems with a data‑driven approach. This role is to serve as a process engineer supporting drug substance active pharmaceutical ingredient (API) manufacturing operations for oligonucleotide, peptide, and bioconjugate purification.

• Perform impact and risk assessments for the relevant equipment (chromatography skids/columns, TFF skids, etc.) and unit operations
• Drive progression of design, qualification supporting documentation, and delivery of purification equipment. This includes representing the process engineering team in Facility Acceptance Testing for assigned equipment.
• Perform equipment walkdowns throughout commissioning and qualification processes to proactively identify issues and provide paths forward to enable on time facility delivery.
• Participate in automation recipe and procedure discussions providing direction on how the equipment needs to be operated to deliver processes
• Mentor junior engineers and drive team technical projects
• Demonstrate a safety‑first mindset and ensure that people and their environment are safe and that company policies concerning safety are followed.
• Ensure processing equipment remains…