Senior Analytical Scientist – Analytical Characterization – Lilly Medicine Foundry

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life‑changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first‑ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact.

• Drive implementation of technical solutions and analytical strategies to enable drug substance production at the Lilly Medicine Foundry leveraging traditional off‑line testing in the laboratories or in‑line/on‑line testing via process analytical technology (PAT) on the production floor.
• Select and implement appropriate analytical techniques (e.g., LC, GC, NMR, MS, XRD) to support chemical process development – independently generating data that elucidates reaction mechanisms, characterizes kinetic behavior, and identifies process‑related impurities.
• Provide technical leadership for analytical and biophysical characterization of a wide variety of molecules. Ensure methods are technically sound, well developed, and fit‑for‑purpose.
• Transfer analytical methods from Product Research and Development laboratories with an emphasis on communication with other analytical scientists while making improvements on test methods to improve robustness, accuracy, precision and other attributes outlined by ICH guidelines.
• Demonstrate high learning agility and the ability to understand and exploit effective scientific concepts and methods across multiple subject areas (chemistry, engineering, analytical sciences, data sciences, etc.).
• Plan and manage short‑term and long‑term development activities. Develop and/or review technical agendas and timelines for project work. Recommend resource allocation to accomplish projects according to plans, communicate progress and propose changes in timeline, objectives, or direction.
• Collaborate closely with organizations across development and manufacturing to deliver material and information for clinical trials and regulatory submissions for multiple modalities (small molecules, oligonucleotides, peptides, antibodies, antibody conjugates, and other modalities).
• Welcome varied perspectives to create new solutions.
• Coordinate instrumentation between different projects to allow equal usage of available tools for project specific needs.
• Author or contribute to technical documents including SOPs, technology transfer documents, process flow diagrams, regulatory submissions, patents, and scientific papers.
• Ensure work and team activities are aligned with all relevant development quality, regulatory, HSE, GLP and GMP requirements.

• B.S. in chemistry, analytical chemistry, chemical engineering, biophysics, biochemistry or a closely related STEM field with >8 years of relevant analytical characterization experience using spectroscopy, chromatography, and other techniques, or M.S. with >5 years of relevant experience.
• Experience with analytical characterization techniques (e.g., NMR, MS, IR, Raman, XRPD) used for the chemical and physical characterization of synthetic and/or biologic modalities.
• Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F‑1 CPT, F‑1 OPT, F‑1 STEM OPT, J‑1,…