DMPK Scientist

Arvinas, a clinical‑stage biotechnology company dedicated to improving patients’ lives by developing therapies that degrade disease‑causing proteins, is seeking an experienced D‑MPK scientist to work on projects from discovery through all stages of development, contributing in areas such as in‑vitro and in‑vivo ADME, animal PK, toxicokinetics, drug metabolism, transporter‑based DDI, ¹⁴C‑ADME studies, QWBA, and human PK prediction.

This role reports to the Head of Nonclinical Sciences and may be based at our headquarters in New Haven, CT or be a remote U.S. position.

• Serve as a project D‑MPK scientist and advise discovery teams on strategies for early ADMET profiling up to the selection of a lead candidate into preclinical development.
• Represent the DMPK function on company‑wide development teams to support the advancement of preclinical and clinical development assets.
• Contribute to the in‑vitro DDI and other in‑vitro/in‑vivo DMPK assessment for individual preclinical drug candidates and ensure timely availability of key data as part of IND‑enabling activities.
• Recommend stage‑appropriate clinical DDI strategy to the clinical pharmacology function.
• Contribute to the outsourcing of DMPK studies and ensure timely and high‑quality conduct of in‑vitro and in‑vivo ADMET studies. Partner with key CROs to develop and customize ADMET assays to support PROTAC drug discovery and development.
• Contribute to the preparation of the DMPK component of regulatory documents such as IND, IB, or other documents.
• Stay up to date with the scientific advances and regulatory landscape for DMPK science in drug discovery and development.

• In‑depth knowledge or expertise on one or several aspects of DMPK science in drug discovery and/or development, such as biotransformation, bioanalysis, pharmacokinetics, toxicokinetics, transporter‑based drug‑drug interaction, PBPK or PK/PD modeling, human PK prediction.
• General knowledge of drug discovery and development process.
• Experience representing the DMPK function on discovery and development teams.
• Ability to integrate DMPK knowledge of individual drugs and prepare DMPK components of regulatory documents.
• Hands‑on experience and proficiency in PK analysis with PK or modeling software such as Phoenix.
• Knowledge of relevant regulatory guidance in areas such as drug‑drug interaction, bioanalysis, and GLP.
• Arvinas does not provide VISA sponsorship for this position. Candidates must have the ability to work in the U.S. without current or future VISA sponsorship.
• The duties of this role are generally conducted in a combination of lab and home‑office environments. Employees must be able to lift/carry 15/30 pounds unassisted/assisted and work comfortably in a controlled environment with biological, infectious, and hazardous materials; use PPE; use a computer; communicate via phone, video, and electronic messaging; engage in problem‑solving, analysis, and dialogue; collaborate with others; and remain generally available during standard business hours.

• Ph.D. in pharmaceutical science, chemistry, biochemistry, or a related scientific discipline with ten-plus years of relevant experience in DMPK in the biopharmaceutical industry or CROs supporting pharmaceutical development, preferably with a focus on small molecules.
• Direct experience with PROTAC, molecular glue, or ADC highly desirable.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more.

Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.