Principal Scientist
Job in
Lenexa, Johnson County, Kansas, 66219, USA
Listed on 2026-08-08
Listing for:
ICON Clinical Research
Full Time
position Listed on 2026-08-08
Job specializations:
-
Research/Development
Research Scientist, Clinical Research, Biotech Research, Medical Science
Job Description & How to Apply Below
ICON plc is a world-leading healthcare intelligence and clinical research organization. We're proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.
Are you a scientist with expertise in method development? Take the next step in your career by joining ICON where you'll advance groundbreaking clinical therapies by leading global client programs.
We are excited to be seeking a new
** Principal Scientist
** at
** ICON
* * in
** Lenexa, Kansas (KS).
** The
** Principal Scientist
** will lead and conduct scientific research aimed at advancing clinical trials and developing innovative therapies. You will manage sponsor programs, shape assay strategies, and provide expertise for new and complex modalities.
We are seeking candidates with robust method development and knowledge in science for new biological modalities.
** What You Will Do*
* This Research Scientist is responsible for method development and validation testing using complex ligand-binding analytical methods. In addition, you will oversee transfer of LBA methods for large molecules for further bioanalytical testing.
** Desired Experience (ligand binding experience required)*
* + Ligand binding assays
+ ELISA, ECLIA
+ PK, PD, and immunogenicity
+ Usage of relevant software (e.g. Soft Max Pro, Watson, or equivalent)
+ Neutralizing antibody or Flow Cytometry experience is beneficial.
** Method Development*
* + Designs and executes experiments for method development under supervision or independently depending on level
+ Develops new scientific approaches to method development and communicates these to the global science team
+ Depending on level the scientist may:
+ Mentor more junior scientists and advise operation on developed methods
+ Reviews and approves data of other scientists
+ Communicate with team members and management regarding project status, purpose, scheduling, problems, etc.
+ Communicate and/or participate in communication with clients regarding project status.
** Scientific*
* + Maintain knowledge and skill in all techniques where you perform your work.
+ Provide scientific input to management and BD about new technology investments and lines of service.
+ Discusses scientific results with sponsors together with project manager
+ Promotes ICON utilizing their scientific skills through scientific communication such as external publication of posters and journal articles.
+ Perform R&D projects
+ Training of technicians on technical aspects
+ Mentor and train staff on scientific topics
** Quality and Timely Work Execution*
* + Takes initiative in process development and SOP/WI writing
+ Legible, logical and reproducible documentation of all experimentation
+ Has a thorough understanding and complies with GLP and other appropriate regulations
+ Develops rugged and economical assays
+ Performs data review of other scientist's work
** Sample Analysis and Assay Validation*
* + Provides key assay input to the validation and bioanalysis team(s) to ensure successful execution
+ Assay troubleshooting
+ May perform and document maintenance, troubleshooting and repairs on advanced instrumentation with support of service engineers or other trained supervisory personnel.
** Qualifications*
* + Read, write and speak fluent English.
+ BS in a scientific discipline required. Advanced degree (MS or PhD), preferred.
+ 5 - 10 years of industry or academic laboratory experience supporting ligand-binding assays.
+ Demonstrated method development experience within the clinical or pharmaceutical industry with a track record of managing scientific projects.
+ Presenter/Publisher in Regulated relevant field, nice to have.
LI-KM3
** What ICON can offer you:*
* Our success depends on the quality of our people. That's why we've made it a priority to build a diverse culture that rewards high performance and nurtures talent.
In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life…
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