Senior Principal Scientist, Bioanalytical

Senior Research Scientist
- Onsite, Lenexa, KS
- Full-Time;
Flow Cytometry

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

We are excited to be seeking a new Senior Principal Scientist at ICON in Lenexa, Kansas (KS). The Senior Principal Scientist will lead and conduct scientific research aimed at advancing clinical trials and developing innovative therapies. You will manage sponsor programs, shape assay strategies, and provide expertise for new and complex modalities.

We are seeking candidates with proven method development and Spectral Flow Cytometry experience.

The Senior Principal Scientist is responsible for method development and validation for testing preclinical and clinical specimens using flow cytometry, and ligand-binding analytical methods. In addition, you will oversee transfer robust flow cytometry methods for further for bioanalytical testing.

• Flow cytometry
  • Experience with Spectral Flow
  • Panel design
  • Gating strategy design
  • Usage of cytometry software (e.g. FACSDiva, FCS express)
• Ligand binding assays
  • ELISA, ECLIA
  • PK, PD, and immunogenicity
  • Usage of relevant software (e.g. Soft Max Pro, Watson)

• Designs and executes experiments for method development
• Develops new scientific approaches to method development and communicates these to the global science team
• Mentors junior scientists and advises operation on developed methods
• Reviews and approves data of other scientists
• Communicates with team members and management regarding project status, purpose, scheduling, problems, etc.
• Lead communication with clients regarding project status.

• Maintain knowledge and skill in all techniques where you perform your work.
• Provide scientific input to management and BD about new technology investments and lines of service.
• Own discussions regarding scientific results with sponsors, together with project manager
• Promotes ICON utilizing scientific skills through scientific communication such as external publication of posters and journal articles.
• Perform R&D projects
• Training of technicians on technical aspects
• Mentor and train staff on scientific topics

• Takes initiative in process development and SOP/WI writing
• Legible, logical and reproducible documentation of all experimentation
• Has a thorough understanding and complies with GLP and other appropriate regulations
• Develops rugged and economical assays
• Performs data review of other scientist’s work

• Provides key assay input to the validation and bioanalysis team(s) to ensure successful execution
• Assay troubleshooting
• May perform and document maintenance, trouble-shooting and repairs on advanced instrumentation with support of service engineers or other trained supervisory personnel.

• Read, write and speak fluent English
• Spectral flow cytometry experience
• 10-15 years of relevant laboratory experience
• MS or PhD with applicable research in a relevant scientific field, preferred
• Presenter/Publisher in Regulated relevant field, preferred

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Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family’s needs.
• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
• Global Employee Assistance Programme, Life Works, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support…