Principal Scientist; Research Scientist

Principal Scientist (Research Scientist)- Bioanalytical, LC/MS/MS) - Full time, Salary, Benefits - Lenexa, Kansas (KS)

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

Are you a scientist with expertise in method development? Take the next step in your career by joining ICON where you’ll advance groundbreaking clinical therapies by leading global client programs.

We are excited to be seeking a new Principal
Scientist (Research Scientist) at ICON in Lenexa, Kansas (KS). The Principal
Scientist ( Research Scientist ) will lead and conduct scientific research aimed at advancing clinical trials and developing innovative therapies. You will manage sponsor programs, shape assay strategies, and provide expertise for new and complex modalities.

We are seeking candidates with strong bioanalytical method development experience and expertise in emerging biological modalities.

The Principal Scientist (Research Scientist) is responsible for method development and validation for testing preclinical and clinical specimens using LC/MS/MS analytical methods. In addition, you will oversee transfer robust LC/MS/MS methods for biologics for bioanalytical testing.

Key responsibilities include:

• Independently direct development and validation of new LC/MS/MS assays using appropriate methods such as (but not limited to) Tomtec, Hamilton, Kingfisher, Integra Assist plus, etc.

• Ensure robust LC/MS/MS methods are developed for successful method validation of both small molecules, radio labeled analytes and biologics such as proteins, peptides, ADCs, oligonucleotides, monoclonal antibodies (mAb), etc.

• Review data presentations for accuracy and clarity prior to sharing with sponsors

• Provide support to Laboratory Operations staff regarding assay quality, expected results, troubleshooting and data review

• Provide technical input for ICON Marketing collateral, attend conferences, publish papers in the peer-reviewed literature

• Drive new business by consulting with sponsors on assay requirements for new projects

• Collaborate with inter-departmental functions to write and review validation plans, reports and SOP’s

• Lead assay transfers to other ICON lab locations

Required qualifications and experience:

• PhD or equivalent degree in a relevant scientific field such as biology, chemistry, pharmacology, or clinical research.

• MS degrees considered with proven LC/MS/MS method development experience in the pharmaceutical or clinical research industry.

• Experience with some or all of the following: radio labeled analytes and biologics such as proteins, peptides, ADCs, oligonucleotides, monoclonal antibodies (mAb), etc.

• Experience in conducting research within the clinical or pharmaceutical industry, with a proven track record of managing scientific projects.

• Strong analytical skills and expertise in data interpretation and statistical analysis.

• Excellent written and verbal communication skills, with the ability to present complex scientific information to both technical and non-technical audiences.

• Willingness to travel as required (approximately 5%)

#LI-KM3

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various…