Process Development Engineer IV, Upstream

About the Role

The Process Development Engineer IV supports upstream cell culture development for both early‑ and late‑stage biotherapeutics programs. In this role, you will design and execute studies, generate and interpret data, and advance processes using a range of upstream technologies, including bench‑top bioreactors, Am  microscale bioreactors, shake flasks, WAVE bioreactors, and high‑throughput purification systems.

You will work cross‑functionally with upstream, downstream, and analytical teams to support program objectives, while contributing to technical documentation and leveraging process control systems such as Delta

V. This position also offers the opportunity to explore and apply emerging tools, including artificial intelligence and in silico approaches, to improve development speed and efficiency.

• Support the design and execution of upstream development studies across early‑ and late‑stage programs
• Collaborate with upstream, downstream, and analytical teams as part of cross‑functional development efforts
• Operate and troubleshoot cell culture systems, including bench‑top bioreactors, Am , shake flasks, WAVE bioreactors, and high‑throughput purification systems
• Utilize Delta
  
  V or similar control systems to support process execution and data collection
• Maintain accurate and timely documentation in electronic laboratory notebooks
• Analyze process data, interpret results, and summarize findings to support development decisions
• Prepare technical reports, study summaries, and supporting documentation
• Learn and apply artificial intelligence and in silico tools to enhance process understanding and efficiency

• Bachelor’s degree with 5+ years, or Master’s degree with 3+ years of relevant experience in biochemical engineering, chemical engineering, biotechnology, biology, or related field
• Experience in biotherapeutics upstream process development
• Hands‑on experience with upstream unit operations, including bioreactors (bench‑top and Am ), shake flasks, and WAVE systems
• Working knowledge of Delta
  
  V or similar process control systems
• Experience using electronic laboratory notebooks
• Strong data analysis and technical writing skills
• Solid understanding of upstream cell culture process development
• Ability to learn and apply new tools and technologies, including AI and in silico methods
• Strong attention to detail with the ability to work independently and collaboratively
• Proven ability to contribute to team objectives and support broader project goals

Location:

Lexington, MA

U.S. Base Salary Range: $ – $

U.S. based employees may be eligible for short‑term and/or long‑term incentives. Employees may participate in medical, dental, vision insurance, a 401(k) plan and company match, short‑term and long‑term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well‑being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

Job Exempt:
Yes

Worker Type:
Employee

Worker Sub‑Type:
Regular

Time Type:
Full time

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.