Director, Commercial Supply Chain

Job Description At uniQure, we are delivering on the promise of gene therapy and delivering hope for patients facing urgent unmet medical needs. Every role in our organization carries profound purpose; whether you're in research, operations, access, or support, your contributions impact patients. We're seeking passionate professionals who thrive in high‑stakes environments, uphold rigorous quality standards, and share our relentless commitment to transforming the lives of patients.

Join us in making the impossible possible, where your expertise becomes a catalyst for life‑changing treatments.

uniQure is seeking an experienced, hands‑on Director, Commercial Supply Chain to build, scale, and run the commercial supply chain for our AAV gene therapy portfolio at a defining moment – as we prepare to launch a pivotal Phase 3 program and ramp toward global commercialization. As a foundational hire within Global Operations, you will stand up the people, processes, systems, and external partnerships required to deliver complex, high‑value, temperature‑sensitive therapies reliably and compliantly to treatment centers and patients worldwide.

This is a role for a leader who is equally comfortable setting multi‑year strategy and rolling up their sleeves to execute day‑to‑day – designing the operating model one week and resolving a shipment or forecast issue the next. In a predominantly outsourced (CDMO/3PL) network, you will own end‑to‑end commercial supply: demand and supply planning, distribution and cold‑chain logistics, launch readiness, and supply chain compliance, working in close partnership with Technical Operations, Quality, Regulatory, Commercial, Finance, and external partners.

You will shape how uniQure’s commercial supply chain scales from first launch to a sustainable, multi‑market operation.

• Design and stand up the commercial supply chain operating model, processes, tools, governance, and organization, fit for a low‑volume, high‑value AAV gene therapy portfolio
• Define and execute a phased roadmap that scales capability from initial launch to a repeatable, multi‑product, multi‑market operation
• Build and lead the commercial supply chain team over time, fostering a performance‑driven, patient‑focused, continuous‑improvement culture
• Balance strategic build with hands‑on execution, personally owning critical tactical activities until the function is scaled

• Drive supply chain strategy and readiness for the Phase 3 program and subsequent global commercial launch, including new markets, indications, and lifecycle expansions
• Develop launch supply plans, network design, and readiness checklists in alignment with product lifecycle management, in partnership with Tech Ops, QA, RA, Clinical Operations and Commercial
• Establish launch governance and cross‑functional alignment, serving as the supply chain single point of contact to product and launch teams
• Ensure treatment‑center and channel readiness, including qualification of specialty distribution and treatment‑site onboarding for gene therapy administration

• Establish and run demand and supply planning and the S&OP/IBP process for the commercial portfolio, managing the lumpy, patient‑driven demand characteristic of gene therapy
• Translate commercial demand signals and market events into actionable, financially sound supply plans; improve forecast accuracy to support reliable supply and inventory management
• Manage constrained, high‑value inventory and CDMO capacity, leading allocation, scenario planning, and trade‑off decisions to protect product availability
• Partner with Finance on forecast assumptions, inventory implications, accruals, budget alignment, and performance follow‑up

• Define and optimize the global distribution network – 3PLs, specialty distributors/pharmacies, and treatment centers – to meet market access models and patient needs
• Own end‑to‑end cold‑/ultra‑cold‑chain logistics, ensuring temperature integrity, chain of custody,…