Principal Scientist - Toxicology

Our Boston Research & Development hub, anchored in the greater Boston area, brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown and Cambridge reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future, creating a distinct R&D community based on collaboration, partnerships, and cutting-edge research across multiple modalities and therapeutic areas.

We recognize that improving human health starts here and that patients rely on us. Our greater Boston R&D hub merges biotech speed and agility with large pharmaceutical company quality, resources, and stability, uniting the best of both worlds to develop new medicines for patients.

The team is comprised of collaborative, diverse and passionate people who have a true sense of pride in their work and are committed to helping others grow and develop their careers. You’ll also have a platform to engage with key stakeholders on a global scale throughout the entire pipeline process. And while changing the future of diabetes, obesity and MASH treatment is no easy task, we also recognize the importance of an enjoyable workplace, which is why we’ve cultivated a culture of fun, ingenuity and innovation.

And our competitive compensation package and support of a healthy work-life balance all add to a best-in-class employee experience. Are you ready to make a difference?

This role is an opportunity to pioneer Novo Nordisk’s strategy for small molecule early safety assessment. The position (Principal Scientist) requires a candidate with deep subject matter expertise in exploratory toxicology for small molecules, and an entrepreneurial spirit to work in the company’s new and growing small molecule pipeline. In this role the candidate will be working together with experienced colleagues in exploratory and computational toxicology and will, as part of the global team, be responsible for small molecule early safety evaluation based on in vitro/in vivo toxicology screening data to support lead optimization and lead candidate selection.

An important part of the role is to guide, manage, and interpret toxicity data performed at contract research organizations (CROs) in close collaboration with project scientists and key program stakeholders/leadership.

The candidate will be part of a subject matter expert team developing Novo Nordisk’s strategy for early investigative/exploratory toxicology. The expert team will serve a critical advisory function by communicating evaluations and implications of the strategy across the value chain of Novo Nordisk’s small molecule pipeline.

The role requires in-depth understanding of subject matter & relationship to other key areas related to small molecule drug development; expert-level guidance for project team related to experimental strategies to evaluate emerging research and technologies related to small molecules; propose & oversee CROs, external collaborations & strategic partnerships to further develop Novo Nordisk goals related to therapy and/or technology areas, including the use of New Approach Methodologies (NAMs) in toxicology.

Reports to the head of Novo Nordisk GDDS Boston toxicology department, co-located with project chemists and ADME scientists, and part of the Novo Nordisk regulatory toxicology team. In addition, important stakeholders will include exploratory toxicologists located in GDDS Denmark, global project managers, non-clinical project managers, scientific leadership, and other colleagues across global R&D. Individual may direct the work of other staff members.

Individuals will interact with external research collaborators both academia- & industry-based.

• Initiating, monitoring and reporting Exploratory Toxicology studies/data
• Supervise the execution of in silico, in vitro and in vivo toxicology studies at CROs/technology providers to assess safety profiles and progress chemical leads.
• Identify and secure optimal exploratory toxicology screening plans in alignment with a cross-functional team including chemists, biologists, and ADME…