Senior Scientist - Drug Metabolism

Our Research & Development organization brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown, Cambridge and Plainsboro reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future, creating a distinct R&D community based on collaboration, partnerships, and cutting‑edge research across multiple modalities and therapeutic areas.

We recognize that improving human health starts here and that patients rely on us. Our R&D hub merges biotech speed and agility with large pharmaceutical company quality, resources, and stability, uniting the best of both worlds to develop new medicines for patients.

The Senior Scientist I will design and conduct absorption, distribution, metabolism and excretion (ADME) research on compounds, drug agents and metabolites in pre‑clinical and/or clinical development. Uses a physicochemical approach, attempting to compile various data such as absorption and excretion rates and drug agent half‑life in order to establish pharmacokinetic profiles of new chemical and/or molecular entities, as well as determining the optimum and safe dosage forms for compounds that have been determined to have indications for various disease groups.

Develops protocols and/or prepares study documentation and findings to support domestic and international submissions of new drugs.

Demonstrates subject‑matter expertise and in‑depth knowledge. Works independently; receives minimal guidance. Acts as a resource for colleagues with less experience; may direct the work of other staff members. Handles specialist tasks of high complexity critical to the company.

Reports to the head of the relevant department. Works closely with technical staff, other members of the scientific leadership team, project managers and colleagues across global R&D. Interacts with external research collaborators in academia and industry.

• Lead DMPK strategy for discovery programs across multiple therapeutic areas, aligning ADME objectives with project milestones.
• Design and interpret in vitro and in vivo ADME studies to inform lead optimization and candidate selection.
• Apply fit‑for‑purpose in silico models, PK/PD, PBPK, exposure–response to predict human pharmacokinetics/dose and de‑risk programs.
• Integrate DMPK data with medicinal chemistry and pharmacology to guide chemical design and prioritize novel chemical matter with favorable drug‑like properties.
• Propose and oversee internal and external research initiatives, including study design, data analysis, and documentation to meet project goals.
• Collaborate with outsourcing managers to identify, qualify and manage CRO partners with specialized ADME capabilities; ensure quality, timelines and cost effectiveness.
• Engage and collaborate with global ADME experts to harmonize methodologies, share best practices and leverage cross‑site expertise.
• Provide scientific mentorship and technical leadership to DMPK team members and cross‑functional colleagues.
• Communicate DMPK strategy, findings and risk assessments clearly to project teams and senior management; contribute to go/no‑go decisions.
• Represent the company externally as needed (publications, conferences, scientific consortia) to build visibility for DMPK methods and capabilities.
• Maintain awareness of emerging DMPK methodologies, regulatory expectations and modeling technologies; implement applicable innovations to improve discovery throughput and predictivity.

• BS/BA with 10+ years of relevant experience; or master’s degree with 8+ years; or PhD with 4+ years required.
• Experience designing and conducting ADME research in a pre‑clinical and/or clinical development setting.
• Excellent understanding of ADME principles with hands‑on experience with PK and PK/PD modeling or biotransformation highly desirable.
• Strong knowledge and experience in pharmacokinetics and drug metabolism.
• Preferred experience includes DMPK or PK/PD modeling project representation.
• Proficiency in scientific communication and stakeholder engagement.

The base compensation…