Senior Scientist , DMPK

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology.

Our diversified pipeline is focused on our obesity, alpha‑1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and also includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Wave Life Sciences is seeking a highly motivated and detail-oriented Scientist with strong expertise in bioanalytical and Drug Metabolism and Pharmacokinetics (DMPK) sciences to support drug development programs from preclinical through clinical stages. The successful candidate will play a key role in independently designing, executing, and interpreting pharmacokinetic (PK), toxicokinetic (TK), plasma protein binding and in vitro drug‑drug interaction (DDI) studies.

This role will be based in our Lexington, MA office with a hybrid work arrangement.

• Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, or related discipline with at least 3 years of relevant experience, or M.S. with at least 6 years of industry experience
• The ideal candidate will have experience supporting the development of RNA-based modalities (e.g., siRNA, antisense oligonucleotides, GalNAc conjugates, etc.)

• Independently design, execute, and interpret in vitro and in vivo studies (i.e., ADME, PK, PK/PD) to support advancement of RNA therapeutic programs
• Autonomously analyze and interpret PK, TK and PK/PD data using appropriate software tools (e.g., Phoenix Win Nonlin), including conducting NCA and graphical exposure‑response analyses
• Represent DMPK function at cross‑functional project team meetings
• With guidance, plan, execute, and deliver DMPK deliverables from lead selection to IND stage
• Collaborate with cross‑functional teams including bioanalysis, discovery research, toxicology, clinical pharmacology, regulatory, and external CROs to meet program goals and timelines
• Prepare high‑quality scientific reports and integrate DMPK data into regulatory documents (IND, CTA, briefing documents, etc.)
• Manage internal and external (CRO) DMPK activities including DDI, PPB, to ensure timely delivery of high‑quality data
• Deliver robust IND/CTA‑enabling DMPK packages to support regulatory filings
• Stay current with regulatory guidance and scientific advances in the field of bioanalysis and DMPK

• Proficient in PK software tools such as Phoenix Win Nonlin and conduct NCA
• Conduct graphical analysis using standard tools like Phoenix Win Nonlin, R, or similar
• Demonstrate sound knowledge of PK/PD principles
• Familiarity with regulatory requirements for nonclinical DMPK studies
• Demonstrate expertise in plasma protein binding and in vitro DDI assessments (e.g., CYP inhibition/induction, transporter interactions)
• Ability to innovate and think creatively to support the drug development process
• Excellent communication, organizational, and teamwork skills
• Knowledge and experience in bioanalysis to support DMPK studies (metabolite identification, biodistribution, etc.)
• Hands‑on experience with modeling and simulation is a plus

The annual base salary range for this position is $157,000 – $213,000.

The range provided is based on what we believe is a reasonable estimate for the annual base salary pay range for this position at the time of posting. Actual annual base salary will vary based on several factors including, but not limited to, relevant skills, experience, qualifications,…