Research Associate II

Job Title:

RESEARCH ASSOCIATE

Location:

65 Hayden Ave Lexington, MA 02421

Duration: 1 year

Reporting Expectations:
Onsite

• mammalian cell culture
• cell-based assays
• quantitative real-time PCR

To provide technical laboratory research effort in support of multiple projects focused on expedited evaluation and the clinical translation of therapies.

• siRNA drug candidate screening, hit identification, and lead optimization
• Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; RNA extraction and RT-qPCR
• Analyze data and present the results in group meetings
• Maintain clear experimental records in laboratory notebooks; write SOPs and other technical reports as needed
• Work closely with research team members to quickly and effectively address critical questions related to the efficacy of our drugs
• Review literature and provide insights to research directions, while predominantly making hands‑on contributions to the research

• Master's in Cell and Molecular Biology or Pharmaceutical Sciences
• 4+ years of relevant drug discovery laboratory experience in industrial or academic environment is preferred
• Experience in cellular and molecular biology is essential (e.g., mammalian cell culture, cell-based assays, quantitative real-time PCR)
• Experience with primary human adipocytes and hepatocytes culture is preferred
• Experience with advanced in vitro model systems including organoids and other 3D culture systems is highly preferred
• Experience with RNAi and in vitro screening is preferred
• Candidate must have strong oral and written communication skills, strong work ethics and demonstrated to be an effective contributor to group projects in a team-oriented environment
• The ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected