Senior Research Associate - In Vitro Pharmacology & Biology

Senior Research Associate - In Vitro Pharmacology & Biology

Facility:
Research

Location:

Lexington, MA, US

Our Research & Development organization brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown, Cambridge and Plainsboro reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future, creating a distinct R&D community based on collaboration, partnerships, and cutting-edge research across multiple modalities and therapeutic areas.

We recognize that improving human health starts here and that patients rely on us. Our R&D hub merges biotech speed and agility with large pharmaceutical company quality, resources, and stability, uniting the best of both worlds to develop new medicines for patients.

The Senior Research Associate will be responsible for strategy implementation and operations for conducting and summarizing non-clinical in vitro studies internally and externally in the support of new drug evaluations. Design, coordinate and report pre-clinical pharmacokinetic and pharmacodynamic in vitro experiments within research projects as part of target validation, target maturation, or mode-of-action studies. Develop and improve in vitro models supporting non-clinical studies, take an active role in research projects and contribute to innovation by identifying and exploring new therapeutic targets and principles.

Communicate evaluations and implications of in vitro data internally, externally and in regulatory submissions as relevant. Demonstrates some subject matter knowledge. Sets and achieves day-to-day operations with some impact on others within or outside the unit. Works on problems of limited scope. Follows standard practices and procedures in analysing situations or data from which answers can be readily obtained. Normally receives general instructions on routine work and detailed instructions on new projects or assignments.

Might require guidance from manager/senior colleagues. Hands-on work of increasing complexity; responsibility for experimental planning, execution & analyses with limited supervisor input; manages personal experimental timelines to meet deadlines for project with input from supervisor; may present ideas or data to team, site, or global project team; develops, optimizes & drafts protocols for methods of moderate complexity with reduced input from supervisor;

contributes to formal study reports & study protocol drafting & review; may mentor junior staff.

Reports to the head of the related research area and may be supervised by a Scientist. This position will interact with the related research area team members and other research groups at Novo Nordisk, as well as global internal stakeholders and external research collaborators. This position will function as an individual contributor.

• Conduct and summarize non-clinical in vitro studies
• Implement strategies and operations for conducting and summarizing non-clinical in vitro studies
• Collaborate with internal and external stakeholders to support new drug evaluations
• Ensure adherence to regulatory requirements and guidelines in conducting studies
• Design and coordinate pre-clinical pharmacokinetic and pharmacodynamic experiments
• Design experimental protocols for pre-clinical pharmacokinetic and pharmacodynamic studies
• Coordinate the execution of in vitro experiments within research projects
• Analyse and interpret data to draw conclusions and make recommendations
• Develop and improve in vitro models supporting non-clinical studies
• Identify opportunities to develop and enhance in vitro models for non-clinical studies
• Conduct literature reviews and stay updated on the latest advancements in in vitro models
• Collaborate with cross-functional teams to implement improvements and innovations in in vitro models
• Communicate evaluations and implications of in vitro data
• Prepare reports and presentations summarizing in vitro data and findings
• Communicate the implications of in vitro data to internal stakeholders, external partners and regulatory authorities
• Contribute to regulatory submissions by providing relevant in vitro data and analysis

Bachelor's or Master's Degree in Cell and Molecular Biology, Biochemistry or Pharmaceutical Sciences preferred

3-5 years of relevant drug discovery laboratory experience in industrial or academic environment preferred

High School Diploma required with 10+ years' relevant experience; or With an Associate or Vocational degree, 2+ years' relevant experience required; BS/BA, 2+ years' minimum relevant experience required; or Masters, with limited to no experience

Familiarity with pre-clinical pharmacokinetic and pharmacodynamic in vitro experiments

Knowledge of experimental design and in vitro model development

Strong understanding of drug discovery processes and target validation

Excellent scientific communication and stakeholder engagement skills