Senior Scientist I - Drug Metabolism

About The Department

Our Research & Development organization brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown, Cambridge and Plainsboro reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future, creating a distinct R&D community based on collaboration, partnerships, and cutting‑edge research across multiple modalities and therapeutic areas.

We recognize that improving human health starts here and that patients rely on us. Our R&D hub merges biotech speed and agility with large pharmaceutical company quality, resources, and stability, uniting the best of both worlds to develop new medicines for patients.

Our Research & Development organization brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown, Cambridge and Plainsboro reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future, creating a distinct R&D community based on collaboration, partnerships, and cutting‑edge research across multiple modalities and therapeutic areas.

We recognize that improving human health starts here and that patients rely on us. Our R&D hub merges biotech speed and agility with large pharmaceutical company quality, resources, and stability, uniting the best of both worlds to develop new medicines for patients.

The Senior Scientist, DMPK will provide scientific leadership in the discovery of small molecule drug candidates by integrating DMPK strategy across multiple therapeutic areas. You will define and drive internal and external research initiatives that support program milestones, proposing experimental and modeling approaches to de risk projects and advance molecules with drug like properties. Working cross functionally with medicinal chemistry, pharmacology and other discovery teams, you will lead DMPK efforts to optimize candidates using in vitro, in vivo and in silico methods where pharmacokinetic/pharmacodynamic (PK/PD) modeling and/or physiologically based pharmacokinetic (PBPK) hands‑on capabilities are required.

You will engage with global Novo Nordisk ADME experts to harmonize strategy and leverage best practices. The successful candidate will be recognized as a subject matter expert in small molecule ADME/PK.

Reports to the Director of GDDS Boston DMPK department at Novo Nordisk. Internal relationships include working closely with technical staff & other members of the scientific leadership team; regular collaborations with members of other research departments at NN; & frequent interaction with project managers & other colleagues across global R&D. Individual may direct the work of other staff members. Individual will interact with external research collaborators both academia‑& industry‑based.

• Lead DMPK strategy for discovery programs across multiple therapeutic areas, aligning ADME objectives with project milestones.
• Apply fit-for-purpose in silico models, PK/PD, PBPK, exposure–response, to predict human pharmacokinetics/dose and de‑risk programs.
• Integrate DMPK data with medicinal chemistry and pharmacology to guide chemical design and prioritize novel chemical matter with favorable drug‑like properties.
• Propose and oversee internal and external research initiatives, including study design, data analysis, and documentation to meet project goals.
• Collaborate with outsourcing managers to identify, qualify and manage CRO partners with specialized ADME capabilities; ensure quality, timelines and cost‑effectiveness.
• Engage and collaborate with global Novo Nordisk ADME experts to harmonize methodologies, share best practices and leverage cross‑site expertise.
• Communicate DMPK strategy, findings and risk assessments clearly to project teams and senior management; contribute to go/no‑go decisions.
• Represent the company externally as needed (publications, conferences, scientific consortia) to build visibility for DMPK methods and capabilities.
• Maintain awareness of emerging DMPK…