Associate Research Scientist Contractor, RNAi Formulations

Job title: Associate Research Scientist Contractor, RNAi Formulations

Location: 65 Hayden Avenue, Lexington, MA, 02421

Duration : 1 year

REPORTING EXPECTATIONS: Onsite;
Monday to Friday, 8:00 AM to 5:00 PM

• Lab experience in formulation of oligonucleotides or antibodies for subcutaneous injection
• Hands on analytical characterization of oligonucleotides or antibodies/protein
• Experience with develop ability assessments, including evaluation of parameters like maximum solubility, viscosity, osmolality, limited chemical and physical stability

• The Associate Research Scientist Contractor, RNAi Formulations, will be based within Non-Viral Delivery (NVD) in Research & Early Development. This is a laboratory-based role focused on hands-on RNAi formulation development, biophysical and analytical characterization, and support of oligonucleotide delivery activities for injectable therapeutics.

• Reports to the US Team Manager for Nucleic Acid Delivery, Formulations and Bioanalysis. Interacts closely with peers and cross-functional partners specializing in non-viral delivery, formulation development, oligonucleotide chemistry, stability assays, PK, bioanalysis, CMC, and external collaborators.

• Support the development and characterization of preclinical RNAi and oligonucleotide formulations across portfolio and platform projects.
• Execute hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and develop ability assessments.
• Establish and run screening assays for oligonucleotides in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, , and stability assessments.
• Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable.
• Support long-term storage and stability evaluations for RNAi conjugates and oligonucleotide formulations.
• Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations.
• Collaborate with internal stakeholders and external partners to support project deliverables and timelines.
• Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows.
• Thrive in a multidisciplinary, fast-paced research environment with competing priorities and tight deadlines.

• MS with approximately 3 years of relevant experience, or PhD with 1-3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleotide delivery, or a related discipline.
• Hands-on experience with oligonucleotide or antibodies/proteins formulation and characterization is strongly preferred.
• Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, , stability, or other develop ability assessments for complex oligonucleotide or antibody/protein formulations.
• Familiarity with automation, high-throughput screening, and DoE-based formulation optimization is an advantage.
• Strong experimental planning, documentation, data analysis, and problem-solving skills.
• Excellent verbal and written communication skills, with the ability to work effectively across disciplines and functions.
• Awareness of external trends and advances in RNA delivery, oligonucleotide therapeutics, and clinical translation is a plus.
• A track record of scientific contributions, publications, or conference presentations in relevant areas is a plus.