Head, Oncology Clinical Development - ADCs

For candidates seeking to be located at our Stevenage site, this role will temporarily be based ever, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

The Head, Oncology Clinical Development- ADCs, will report to the SVP, Head of Oncology Clinical Development. The role holder will be accountable for the design and implementation of the clinical development strategy across a particular asset across multiple tumor types spanning early- and late-phase development. This includes the strategic clinical positioning of the asset, combinations, and associated clinical development plans.

This role requires an experienced, cross-matrix senior leader capable of implementing and executing an integrated clinical strategy in support of the successful clinical development, translational research, regulatory filing and initial market launch of a growing portfolio of innovative and transformational Oncology agents.

Accountable for end-to-end clinical development of an MOA-focused, multi-tumor asset, including registrational trials, regulatory approval, and initial market launch, ensuring scientific rigor, speed, and quality of execution.
Shape and drive the scientific and clinical development strategy for the asset and disease areas, aligned with Oncology Tumor Team strategy and broader Oncology portfolio priorities.
Evaluate, champion, and enable the use of novel approaches (e.g., AI/ML, innovative trial designs, external and real-world data sources) where they add clear scientific, operational, or decision‑making value to clinical development.

Provide oversight and connectedness across the asset program, maintaining visibility to progress, risks, dependencies, and trade‑offs across the Oncology portfolio.
Serve as the default senior clinical representative at key governance forums (e.g., DRB, PIB, program and portfolio governance) for the asset, ensuring strong clinical leadership, continuity, and high‑quality decision‑making.
Represent the Oncology Clinical Development organization internally and externally, including presenting at high‑impact forums such as congress all‑hands, senior leadership reviews, and advisory boards.
Lead scientific advisory boards and other external engagements to inform asset strategy, competitive positioning, and portfolio decisions, incorporating emerging science and external expert insight.

Act as a senior connector across functions, partnering closely with Oncology Research, Precision Medicine/Companion Diagnostics, Medical Affairs, Commercial, Competitive Intelligence, and Global Product Strategy to drive integrated development and lifecycle planning.
Drive asset alignment across research, development, and commercialization planning, and ensuring cohesive execution against shared objectives.
Build and sustain strong internal and external partnerships to accelerate decision‑making, resolve complexity, and optimize development outcomes in a matrixed environment.

Foster a culture of empowerment, scientific excellence, inclusion, and collaboration, aligned with One Oncology values, while modeling strong, visible leadership.
Actively remove organizational barriers and enable teams to operate effectively and autonomously within a complex, global matrix environment.

Contribute to the establishment and continuous evolution of…