Postdoctoral Research Associate in Proteomics; LC-MS​/MS

What You Will Do

Los Alamos National Laboratory (LANL) Bioscience Division, Biochemistry and Biotechnology Group (B-TEK) is seeking a proteomics-focused Postdoctoral Research Associate to design, execute, and improve large-scale proteomics pipelines. This role emphasizes high-throughput LC-MS/MS proteomics from sample preparation through quantitative/qualitative analysis and bioinformatics, with a strong focus on rigorous quality control to ensure defensible results across mission-relevant studies. You will work in a highly collaborative environment with access to multiple high-resolution Orbitrap platforms and high-performance computing resources.

The position includes opportunities to publish in high-impact journals and present at conferences.

• Design and execute LC-MS/MS proteomics experiments (DDA and/or DIA) including sample preparation, acquisition, and downstream analysis.
• Develop and/or refine quantitative proteomics workflows with and without isobaric labeling, as appropriate to the study design.
• Implement, track, and document QC standards (reference, quantitative, process control, and system-performance controls) across studies.
• Integrate proteomics results with biological context and complementary measurements; contribute to multi-omics efforts when relevant.
• Communicate results through peer-reviewed publications, technical reports, and conference presentations.

• Ph.D. in a STEM field completed within the last five years (or expected by the start date).
• Strong peer-reviewed publication record commensurate with career stage.
• Demonstrated excellence in written and oral communication (e.g., manuscripts, reports, presentations).
• Deep understanding of mass spectrometry fundamentals and
  -omics pipeline concepts.
• Hands‑on experience spanning sample preparation, instrument operation/data acquisition, and analysis.
• Ability to obtain a DOE Q clearance (typically requires U.S. citizenship).

• Demonstrated experience with large-scale proteomics studies and quantitative LC-MS/MS data analysis.
• Experience with DDA/DIA, spectral library approaches, and/or advanced analysis modalities (e.g., de novo or top-down) is a plus.
• Experience establishing QC methods addressing background, extraction efficiency, precision, reproducibility, and standards/sample pools.
• Familiarity with common proteomics software ecosystems (e.g., Proteome Discoverer, Perseus, Max Quant, or similar).
• Experience with automation/robotics for sample preparation is a plus.

• Current resume/CV
• Current official transcripts
• Cover letter/personal statement of interest, not to exceed one page

Due to federal restrictions contained in the current National Defense Authorization Act, citizens of the People's Republic of China, the Islamic Republic of Iran, the Democratic People's Republic of North Korea, and the Russian Federation, who are not Lawful Permanent Residents are prohibited from accessing facilities that support the mission, functions, and operations of national security laboratories and nuclear weapons production facilities, which includes Los Alamos National Laboratory.

This position is located in Los Alamos, NM. Candidates may work a 9/80 schedule at the discretion of management and in accordance with the Postdoc Program Resource Guide. Initial appointment is for two years; a third year may be possible based on performance and programmatic need. Exceptional candidates may be considered for LANL Director's Fellowships and named fellowships.

Located in beautiful northern New Mexico, Los Alamos National Laboratory (LANL) is a multidisciplinary research institution engaged in strategic science on behalf of national security.

• PPO or high deductible medical insurance with a large nationwide network.
• Dental and vision insurance.
• Free basic life and disability insurance.
• Paid childbirth and parental leave.
• Award‑winning 401(k) (6% matching plus 3.5% annually).
• Learning opportunities and tuition assistance.
• Flexible schedules and time off (PTO and holidays).
• Onsite gyms and wellness programs.
• Extensive relocation…