Postdoctoral Research Associate in Computational Protein Engineering

What You Will Do

Los Alamos National Laboratory (LANL) Bioscience Division, Genomics and Bioanalytics (B-GEN) is seeking a highly motivated, productive, and multi-talented postdoctoral researcher to pursue research applying artificial intelligence and machine learning to engineer proteins for environmental bioremediation applications. This interdisciplinary position uniquely combines computational modeling with experimental protein engineering and biochemistry. Thus, the ideal candidate would have experience in both computational and experimental methodologies, including protein structural modeling, protein docking, molecular biology, and cell culturing.

This position offers the opportunity to contribute to cutting-edge research while developing expertise in both computational and experimental approaches. Additional projects of interest will also be available depending on candidate interests.

• Perform protein structural modeling and rational protein design to improve a target enzymatic activity
• Perform computational analysis of protein structures and dynamics to identify target mutations for improved activity
• Contribute to experimental validation of engineered proteins, including cloning, expression, purification, and characterization
• Effectively communicate results in both written, graphical, and oral formats

• Ph.D. in a relevant STEM field completed within the last five years (or expected by the start date). Dissertation defense must be completed by position start date, with letter from university assuring degree completion if starting before commencement ceremonies
• Preferred training in protein modeling, including structural prediction (Alpha Fold, Rosetta) and protein docking
• Hands-on laboratory experience with molecular biology techniques (cloning, protein expression, purification) and cell culturing
• Strong peer-reviewed publication record commensurate with career stage
• Demonstrated excellence in written and oral communication (e.g., manuscripts, reports, presentations)
• Ability to obtain a DOE Q clearance (required U.S. citizenship)

• Demonstration of effectively bridging computational and experimental approaches
• Experience with molecular dynamics simulations
• Experience with plasmid construction and bacterial transformation techniques
• Proficiency in data visualization and statistical analysis tools

• Current resume/CV
• Current official transcripts
• Cover letter/personal statement of interest, not to exceed one page

The work location for this position is onsite and located in Los Alamos, NM. All work locations are at the discretion of management.

This position is located in Los Alamos, NM. Candidates may work a 9/80 schedule at the discretion of management and in accordance with the Postdoc Program Resource Guide. Initial appointment is for two years; a third year may be possible based on performance and programmatic need. Exceptional candidates may be considered for LANL Director's Fellowships and named fellowships.

Due to federal restrictions contained in the current National Defense Authorization Act, citizens of the People's Republic of China-including the special administrative regions of Hong Kong and Macau-as well as citizens of the Islamic Republic of Iran, the Democratic People's Republic of Korea (North Korea), and the Russian Federation, who are not Lawful Permanent Residents ("green card" holders) are prohibited from accessing facilities that support the mission, functions, and operations of national security laboratories and nuclear weapons production facilities, which includes Los Alamos National Laboratory.

Located in beautiful northern New Mexico, Los Alamos National Laboratory (LANL) is a multidisciplinary research institution engaged in strategic science on behalf of national security. Our generous benefits package includes:

• PPO or High Deductible medical insurance with the same large nationwide network
• Dental and vision insurance
• Free basic life and disability insurance
• Paid childbirth and parental leave
• Award-winning 401(k) (6% matching plus 3.5% annually)
• Learning opportunities and tuition assistance
• Flexible schedules and time off (PTO and holidays)
• Onsite gyms and wellness programs
• Extensive relocation packages (outside a 50 mile radius)

Directive 206.2 - Employment with Triad requires a favorable decision by NNSA indicating employee is suitable under NNSA Supplemental Directive 206.2. Please note that this requirement applies only to citizens of the United States. Foreign nationals are subject to a similar requirement under DOE Order 142.3A.

Position will be cleared to this level. Selected applicants will be subject to a background investigation conducted by or on behalf of the Federal Government, and must meet eligibility requirements
* for access to classified matter. This position requires a Q clearance, and…