Discovery ADME Project Leader

Job Title:

Discovery ADME Project Leader

• Keep Safety as a priority.
• Develop and execute integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
• Integrate ADME and pharmacology to enable translational simulations/modeling for dose selection, PK/PD design, efficacy, and safety studies.
• Define stage-, modality-, and issue-appropriate profiling and decision funnels (in silico, in vitro, in vivo to translational modeling).
• Guide compound design/optimization using data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
• Serve as ADME strategy and single-point-of-accountability on cross-functional program teams; translate ADME findings into design/test hypotheses.
• Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; support go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
• Represent ADME in portfolio governance and leadership reviews.
• Implement best practices, assay innovation, and automation; drive continuous improvement in data reporting/knowledge/decision frameworks; leverage AI/agentic tools where possible.
• Maintain inspection-ready documentation aligned with regulatory expectations.
• Mentor, teach, and grow junior scientists.

• PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
• 3+ years post-graduation industry experience in drug discovery; leadership impact on discovery lifecycle (Design, Make, Test, Analyze).

• Deep ADME expertise; working knowledge of medicinal chemistry and Toxicology principles.
• Experience translating technical concepts into strategic value for senior leadership and cross-functional partners.

Geography:
Boston MA, Louisville CO, or Indianapolis IN.

• 401(k), pension, vacation, medical/dental/vision/prescription benefits, flexible benefits, life insurance/death benefits, time off/leave, well-being benefits (EAP, fitness, employee clubs/activities).