Senior Principal Scientist, Aging and Metabolism

Responsibilities

• Lead translational pharmacology activities across multiple Aging and Metabolism programs from target validation through candidate selection and early clinical translation.
• Drive scientific strategy and critical decision-making through integration of disease biology, pharmacology, biomarkers, human genetics, and clinical data.
• Contribute to portfolio prioritization, governance reviews, and evaluation of external innovation opportunities.
• Establish and manage collaborations with academic institutions, Contract Research Organizations (CROs), biotechnology companies, and other external partners.
• Present scientific strategies and recommendations to senior leadership and governance committees.
• Provide leadership for target validation, mechanism-of-action studies, assay development, candidate profiling, and translational pharmacology activities.
• Develop biomarker strategies, translational packages, and pharmacology plans supporting proof-of-mechanism and proof-of-concept studies.
• Guide the application of human disease models, pharmacodynamic biomarkers, and Pharmacokinetics/Pharmacodynamics (PK/PD) frameworks to support dose selection and patient stratification.
• Integrate receptor pharmacology, G protein-coupled receptor (GPCR) biology, cell signaling, and translational science to maximize probability of technical and clinical success.
• Serve as a subject matter expert, ensuring scientific rigor, quality, reproducibility, and translational relevance across programs.
• Collaborate closely with Discovery, DPDS, Biomarkers, Clinical Pharmacology, Quantitative Sciences, Translational Medicine, Regulatory, and external partners.
• Provide scientific mentorship and leadership across matrix teams.
• Foster a culture of innovation, scientific excellence, accountability, collaboration, and patient-focused decision making.

• A minimum of a Ph.D. in Pharmacology, Physiology, Cell Biology, Molecular Biology, Biochemistry, Biomedical Sciences, or a related scientific discipline is required.
• A minimum 10 years of pharmaceutical or biotechnology experience is required.
• Demonstrated experience in the following is required: in vitro pharmacology; target validation; assay development; mechanism-of-action studies; translational research.
• Strong knowledge of the following is required: receptor pharmacology; GPCR biology; cell signaling; biomarkers; PK/PD; translational medicine.
• Experience in the following is preferred: muscle biology; aging biology; metabolism; obesity; cardiovascular disease; heart failure.
• Experience supporting the following is preferred: biologics; multi-specific antibodies; peptide therapeutics; RNA-based medicines; gene-silencing technologies; targeted delivery platforms.
• Experience evaluating external innovation and business development opportunities is preferred.
• Proven ability to provide leadership within multidisciplinary drug discovery teams is required.
• Must have excellent verbal and written communication skills.
• Must be strategic with a strong scientific mindset.
• The ability to operate effectively within a highly coordinated, fast-paced matrix environment is required.

Demonstrates expertise in translational pharmacology, integrating disease biology, pharmacology, and clinical data to drive scientific strategy and decision-making. Proven leadership in target validation, assay development, and collaboration with multidisciplinary teams in the pharmaceutical and biotechnology sectors.