Medical Research Tech III - Bioinformatics Tech

Position Description

Employees in this classification provide support in an assigned research laboratory conducting specified phases of research projects and assist the P.I. in maintaining a supportive and collegial working environment that fosters exchange of ideas and enhances scientific progress. You will perform work independently and are responsible for developing new procedures and techniques to be utilized in the laboratory and in experiments, and new applications for standard procedures and techniques.

Work is performed under usual laboratory conditions. Some hazards may be present due to use of radioactive, carcinogenic or other potentially harmful substances. Responsibilities also include ensuring overall cleanliness of the laboratory and laboratory equipment, and ordering and maintaining an adequate stock of necessary supplies. May instruct or direct work of subordinate laboratory personnel.

Employees in this classification provide support in an assigned research laboratory conducting specified phases of research projects and assist the P.I. in maintaining a supportive and collegial working environment that fosters exchange of ideas and enhances scientific progress. You will perform work independently and are responsible for developing new procedures and techniques to be utilized in the laboratory and in experiments, and new applications for standard procedures and techniques.

Work is performed under usual laboratory conditions. Some hazards may be present due to use of radioactive, carcinogenic or other potentially harmful substances. Responsibilities also include ensuring overall cleanliness of the laboratory and laboratory equipment, and ordering and maintaining an adequate stock of necessary supplies. May instruct or direct work of subordinate laboratory personnel.

• Assist the Laboratory Manager and P.I. in managing and promoting laboratory safety.
• Perform bioinformatic analyses of large DNA datasets; for example, RNA-sequence and 3’-end RNA sequence data from wild-type and mutant mouse samples.
• Use the ‘R’ programming environment to analyze large DNA datasets.
• Collaborate with P.I, students, and other technical personnel in training new students, postdocs and other investigators in various scientific procedures such as preparation of talks, grants and publications.
• Maintain a record of experiments in a laboratory notebook, including detailed methodology, calculations, data graphs, images of protein blots (“Westerns”), interpretations of data, and indications of errors or unexpected outcomes.
• Supervise lab support activities such as dishwashing, ordering, cleaning, autoclaving solutions and stuffing pipette tip boxes) by student assistants and provide these services when student assistants are absent.
• Help maintain essential laboratory equipment (check
  -80° and
  -20° freezer temperatures) and records (animal use and breeding colony records, material safety data sheets, biohazardous materials and order invoices).

Bachelor's degree in one of the sciences, or equivalent combination (4 years) of job-related experience and college education. Experience may be substituted for college education on a year for year basis.

• Bachelor's degree in biology, mathematics, computer science/ engineering or data science.
• Experience analyzing large-scale genomic, transcriptomic and epigenomic data, such as RNA-Seq, scRNA-Seq and ChIP-Seq, multivariate statistical analysis, bioinformatics and data visualization.
• Experience with Linux/MacOS command line (file management and automation; system monitoring and troubleshooting);
  
  Experience with R & Python (data wrangling and visualization), cloud/high performance and computing (cluster management, e.g., Slurm and parallel computing);
  Experience with data analysis and documentation (e.g., Jupiter notebooks and code annotation);
  Version control;
  Pipeline development and testing.
• Experience and/or knowledge with RNA-Seq technologies; familiarity with scientific equipment, working with advanced instrumentation.

Resume / CV

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