Scientific Software Developer II – Modeler

At Cadence, we hire and develop leaders and innovators who want to make an impact on the world of technology.

Open Eye, Cadence Molecular Sciences – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion®, the only cloud‑native fully integrated software‑as‑a‑service molecular modeling platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization, and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances.

Open Eye, Cadence Molecular Sciences is headquartered in Santa Fe, N.M., with offices in Boston, Mass.;
Cologne, Germany; and Tokyo, Japan.

• Extend Open Eye’s programming toolkits by developing and implementing new and useful scientific and technical features to aid customers in developing bespoke solutions.
• Explore methods for further enhancing Open Eye’s virtual screening platform (including OMEGA, ROCS, FastROCS, OEDocking).
• Apply chemistry/cheminformatics expertise with ML experts to build robust, scalable models to support data‑driven decision making.
• Work on retrospective and prospective projects both internally and with collaborators to validate methodologies.
• Work with the Orion project team to further optimize compound design workflows in Orion.

• PhD (or equivalent experience) in computational chemistry, chemistry, cheminformatics, or related field with 0–3 years relevant experience.
• Knowledge of traditional computational chemistry approaches such as docking, virtual screening, and molecular modeling.
• Programming expertise, ideally in C++ and/or Python, preferably with experience using AI coding agents.
• Experience in or desire to learn about the pharmaceutical industry.
• Strong desire to find practical solutions to challenging problems.
• Demonstrated ability to work both as part of a team and independently.
• Plus (not required):
  Experience with Open Eye software/toolkits; expertise with diffusion models, transformers, or 3D ML representations; experience with synthetically accessible, pharmaceutically relevant generative chemistry.

We are passionate about the welfare of our employees and offer competitive benefits that include medical, dental, vision, a flexible working schedule, 401(k) retirement plans, paid vacation, paid sick leave, home internet costs, public transportation reimbursement, and much more.

Please submit your cover letter and resume as one document.

Open Eye Scientific Software is an Equal Opportunity Employer. We’re doing work that matters. Help us solve what others can’t.