Director, Commercial Excellence, Rare Disease

Role Description

The Director, Commercial Excellence – Rare Disease will act as an operational leader and trusted partner to the Vice President, Rare Disease, ensuring that business priorities are translated into effective plans, decision forums, performance management, and cross‑functional execution. This role will drive the operating infrastructure and organizational coordination needed to deliver on Rare Disease business objectives.

The Director will also ensure that leadership has integrated, actionable insight across the patient and commercial funnel, enabling timely decisions, strong execution, and effective collaboration across Commercial, Medical, Market Access, Patient Services, Finance, Legal, and Compliance.

• Act as a trusted strategic partner to the VP, Rare Disease, helping shape priorities, convert strategy into executable plans, and ensure follow‑through on key business decisions.
• Lead the operating rhythm of the Rare Disease business, including leadership team meetings, performance reviews, trimester business reviews, planning cycles, governance forums, and action tracking.
• Own business performance visibility by synthesizing inputs from Analytics, Sales Force Effectiveness, Finance, and other stakeholders into clear, decision‑oriented insights on performance, risks, opportunities, and required actions.
• Create and maintain an integrated view of the patient and commercial funnel, aligning Field, Marketing, Patient Services, and leadership on the metrics, business drivers, and interventions that matter most.
• Partner with Sales Operations to support targeting, segmentation, call planning, and territory design, ensuring recommendations are commercially sound, practical, and field‑ready.
• Partner with Sales Operations to support incentive compensation plan design, goal setting, payout governance, and ongoing evaluation so incentives reinforce desired rare disease behaviors and business priorities.
• Serve as business owner for CRM and core commercial systems, setting priorities, improving adoption, enhancing business processes, and ensuring alignment with compliance, operational, and user needs.
• Lead high‑priority cross‑functional initiatives, including launch readiness, patient finding capabilities, referral network development, and other strategic programs critical to business growth.
• Drive alignment and execution across Commercial, Medical, Market Access, Patient Services, Finance, Legal, Compliance, and other key partners by identifying barriers, resolving issues, and accelerating decisions.
• Elevate executive effectiveness by preparing high‑quality leadership briefs, presentations, business updates, and strategic materials for U.S. and global stakeholders.
• Lead the development and coordination of high‑quality content for key business meetings, including Business and Budget Reviews, Board of Directors presentations, Joint Steering Committee meetings, and other leadership forums.
• Establish clear governance, accountability, and communication processes to ensure key initiatives remain on track and leadership has transparency into progress, dependencies, and risks.
• Promote a culture of operational excellence, continuous improvement, data‑driven decision‑making, and cross‑functional collaboration across the Rare Disease organization.
• Apply prior experience working across markets or with global partners to support strong alignment between regional execution and broader organizational priorities.

• Bachelor's degree required; advanced degree preferred in business, life sciences, public health, or related field.
• Significant experience in biotechnology, pharmaceuticals, or rare disease, with substantial experience in commercial operations, business operations, strategy, sales operations, consulting, or related functions.
• Strong understanding of rare disease commercial models, including patient journey complexity, referral dynamics, patient finding, access considerations, and field force effectiveness.
• Strong business acumen with ability to connect strategy, operational execution, and financial outcomes.
• Demonstrated success supporting senior executives and leading…