Senior Director, Solid Tumor Asset Lead, Translational Development

Overview

Challenging. Meaningful. Life-changing. Those words describe the experience at Bristol Myers Squibb. This role supports translational development in solid tumor oncology, with a focus on developing and executing biomarker strategies for clinical programs, patient selection, resistance mechanisms, combinations and indications. The Asset Lead collaborates with cross-functional teams and external partners to generate translational data and contribute to regulatory submissions.

We are looking for experienced translational scientists with a strong scientific background, effective communication skills, and experience working in a matrixed industrial environment.

The Asset Lead will be responsible for development and execution of translational strategies in solid tumor oncology for assigned programs. Key responsibilities include acting as a lead scientist to implement and deliver innovative biomarker strategies for clinical programs and developing reports/publications on translational data to support asset development and regulatory submissions. This role works on cross-functional project teams and engages with external academic collaborators and Key Opinion Leaders (KOLs).

• Integrate translational research and clinical development, developing biomarker strategies aligned with clinical development objectives; lead data generation, interpretation, and communication to development teams.
• Understand external research environment and partner with internal and external functions to coordinate translational development deliverables.
• Engage functional groups to develop, champion, implement and align biomarker strategies for development projects to support R&D portfolio goals.
• Define, revise and progress translational biomarker plans in collaboration with teams and matrix leadership.
• Analyze progress, apply critical thinking, and solve problems to deliver key data and interpretations for decision making.
• Deliver high-quality biomarker strategies for mechanism of action/resistance, target engagement, pharmacodynamics endpoints and patient selection.
• Ensure biomarker plan outputs meet established project standards.
• Align biomarker strategies with clinical operational plans and functional capabilities to deliver robust translational biomarker data packages supporting trials and programs.
• Build productive relationships with team members interacting with the translational clinical biomarker group.
• Interface with functional areas to ensure strategic alignment and identify resources to deliver biomarker goals.
• Communicate biomarker program information, risks, and milestones, and manage information flow across team members.

• Ph.D. in Oncology/Hematology or related field with 12+ years of industry experience including significant translational work.
• Comprehensive knowledge of principles, concepts and methodologies within drug discovery or clinical development.
• Significant understanding of translational research/medicine and clinical biomarkers in drug development.
• Demonstrated knowledge of oncology and/or tumor-immunology disease biology.
• Strong understanding of modality-agnostic therapies including small molecules and biologics.
• In-depth understanding of solid tumor oncology with knowledge of current and evolving clinical landscape; therapeutic-area experience is a plus.
• Strong scientific background with demonstrated impact using clinical, translational, and mechanistic data.
• Understanding of early or late-stage drug and translational development with a proven track record of biomarker strategy implementation.
• Clinical protocol authoring and regulatory document review experience.
• Working knowledge of biomarker platforms including genomics, gene expression, immune profiling, and flow cytometry.
• Excellent data analysis and problem-solving skills.
• Exceptional verbal and written communication skills, with experience developing manuscripts, scientific presentations, and regulatory submissions (INDs/NDAs) and the ability to synthesize complex concepts.
• Proven track record of writing and publishing scientific articles as a major contributor.
• Leadership experience on complex…