Scientist, Research Scientist, Clinical Research

Overview

Scientist role at UW School of Medicine and Public Health. The Engin Lab in the Department of Biomolecular Chemistry seeks a Scientist to contribute to research on the mechanism of type 1 diabetes, cellular stress responses, organelle dysfunction, beta cell physiology and pathology.

Job Category:
Academic Staff

Employment Type:

Regular
Job Profile:
Scientist I

The Engin Lab studies how cellular stress responses and organelle dysfunction affect beta cell biology and autoimmune diabetes. Current projects include molecular mechanisms of cellular stress in pancreatic beta cells, ER-mitochondria communication, cellular senescence and crosstalk between stressed beta cells and immune cells. Work involves beta cell or immune cell–specific mouse models, cell culture (primary mouse and human islets), biochemical and immunological assays.

See enginlab.org for more information.

The Engin Lab offers training on grant writing and supports attendance at national meetings to disseminate scientific findings. Candidates are expected to:

• Design and conduct experimental work using state-of-the-art technologies, in vitro and in vivo.
• Perform data analysis and interpretation of results.
• Participate in multidisciplinary research collaborations.
• Write technical documents for fellowships and grants and craft manuscripts for publication.
• Present data in group meetings, seminars and conferences.
• Assist with training of junior scientists, students and technicians in the lab.
• Contribute to shared lab duties.

Candidates who demonstrate the following knowledge, skills and abilities will be given first consideration:

• Molecular biology, RNA, protein work and cloning
• At least three years of experience with mammalian cell culture and gene manipulation (over-expression via adeno or lentiviral transduction, siRNA or CRISPR-mediated knockdown)
• Flow cytometry (complex panel with more than 8 colors)
• Confocal imaging of cells and tissues
• Prior knowledge of cell stress or senescence

Applicants for this position will be considered for Scientist I and Scientist II titles. Title is determined by experience and qualifications of the finalist.

• Attend and assist with scholarly events and presentations to support professional development and dissemination of research.
• Collect and analyze research data, conduct experiments, document results per policies under supervision.
• Write or assist in developing grant applications and proposals.
• Conduct literature reviews, prepare reports and disseminate information.
• Serve as a main point of contact with internal and external stakeholders.
• Assist with identifying research problems and developing methodologies.

School of Medicine and Public Health, Department of Biomolecular Chemistry, Engin Laboratory. The department conducts world-class research focused on molecular mechanisms of biological processes related to human disease and fosters teaching and training. The department values diversity and inclusion.

Starting salary is $65,000 and negotiable based on experience. Benefits include vacation, holidays, sick leave, insurances, and retirement plans. See campus benefits page for details.

• At least 3 years of post-doctoral experience with mammalian cell culture and gene manipulation (over-expression via adeno, lentiviral or retroviral vectors; gene knockdown via si/shRNA or CRISPR).
• Experience in cloning, molecular biology techniques, RNA extraction, qPCR, and Western blot.
• Expertise in molecular and cell biology.

• Experience with mouse models and mouse or human islets
• Drug applications in mice and tissue collection
• Confocal imaging experience
• Research experience in cell stress, senescence, immunology or organelle biology

Ph.D. is required; focus in molecular biology, cell biology, immunology, biochemistry, or related field.

To apply, choose either “I am a current employee” or “I am not a current employee” under Apply Now. You will be prompted to upload your application materials. Important: there is only one attachment field; all required documents must be combined into a single…