Scientist, Research Scientist

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Academic Staff

Regular

Scientist I

The Engin Lab in the Department of Biomolecular Chemistry is looking for a Scientist to contribute to our focus in understanding the mechanism of type 1 diabetes. The Engin Laboratory is focused on understanding how cellular stress response and organelle dysfunction play a role in beta cell physiology and pathology. Current projects involve studying molecular mechanisms of cellular stress responses in pancreatic beta cells in autoimmune diabetes, ER-mitochondria communication, cellular senescence and the crosstalk between stressed beta cells and immune cells.

The work involves working with the beta cell or immune cell–specific mouse models of the stress response genes and mechanistic studies using cell culture (primary mouse and human islets), biochemical and immunological assays (Engin et al., Sci Transl Med 2013, Lee et al., Cell Metab 2020, Chen et al., Nat Comm 2022). More information about our research and publications can be found .

The Engin Lab offers training on grant writing, supports lab members to attend national meetings and disseminate their science. Candidates will be expected to:

• Design and conduct experimental work using state of the art technologies, both in vitro and in vivo.
• Perform data analysis and interpretation of results as required.
• Participate in multidisciplinary research collaborations.
• Write technical documents for fellowships and grants and craft manuscripts for publication.
• Present data in group meetings, seminars and conferences.
• Assist with training of junior scientists, students and technicians in the lab.
• Contribute to shared lab duties.

Candidates who demonstrate the following knowledge, skills and abilities will be given first consideration:

• Molecular biology, RNA, protein work and cloning.
• At least three years of experience with mammalian cell culture. Gene manipulation including adeno or lentiviral transduction, siRNA or CRISPR-mediated knockdown.
• Flow cytometry (complex panel with more than 8 colors).
• Confocal imaging of cells and tissues.
• Prior knowledge of cell stress or senescence.

Applicants for this position will be considered for Scientist I and Scientist II titles. The title is determined by the experience and qualifications of the finalist.

• Conduct literature reviews, prepare reports and materials, and disseminate information to appropriate entities.
• Write or assist in developing grant applications and proposals to secure research funding.
• Collect and analyze research data, conduct experiments and interviews, and document results according to established policies and procedures under general supervision and limited responsibility.
• Attend and assist with the facilitation of scholarly events and presentations in support of continued professional development and the dissemination of research information.
• Assist with the identification of research problems and the development of research methodologies and procedures.
• Serve as a main point of contact and liaison with internal and external stakeholders providing information and representing the interests of a specialized research area.

School of Medicine and Public Health, Department of Biomolecular Chemistry, Engin Laboratory

The starting salary for the position is $65,000; negotiable based on experience and qualifications.

Employees in this position can expect to receive benefits such as generous vacation, holidays, and sick leave; competitive insurances and savings accounts; retirement benefits. For more information, refer to the campus benefits webpage.

• Minimum of 3 years of postdoctoral experience, with no more than 15 years of post-PhD research experience.
• Experience in mammalian cell culture and genetic manipulation techniques, including gene over-expression (adenoviral, lentiviral, or retroviral systems) and gene silencing (siRNA/shRNA and/or CRISPR-based approaches).
• Hands‑on experience with cloning and core…