Cryo-EM Scientist

Job Summary

The UW-Madison Cryo-EM Research Centers comprise two facilities: the Department of Biochemistry Cryo-EM Research Center and the NIH-funded Midwest Center for Cryo-ET. These centers house state‑of‑the‑art cryo‑electron microscopy and cryo‑electron tomography instruments, including multiple Titan Krios TEMs, a Talos Arctica TEM, cryo‑FIB‑SEMs, and advanced sample preparation and computational infrastructure. The Cryo‑EM Scientist will train new users, operate the instruments on behalf of users, develop advanced analytical techniques, stay abreast of community advances, and represent the centers at meetings, conferences, and peer‑reviewed publications.

• Facilitate scholarly events and presentations supporting professional development and dissemination of research information.
• Collect and analyze research data, conduct experiments and interviews, and document results according to established policies and procedures.
• Assist in identifying research problems and developing research methodologies and procedures.
• Serve as the main point of contact and liaison with internal and external stakeholders, representing the interests of the specialized research area.
• Conduct literature reviews, prepare reports and materials, and disseminate information to appropriate entities.
• Write or assist in developing grant applications and proposals to secure research funding.

Minimum starting salary for a Scientist I is $65,000, $75,000 for a Scientist II, depending on experience and qualifications. Employees will receive generous vacation, holidays, sick leave; competitive insurance; savings accounts; and retirement benefits.

• Relevant research experience in the biological sciences, including cell biology, microbiology, protein biochemistry or related sub‑discipline.
• Experience with microscopy, including light microscopy (fluorescence), electron microscopy, and/or cryo‑electron microscopy.
• Experience with cryo‑preparation techniques such as plunge‑freezing, high‑pressure freezing, cryo‑microtomy, cryo‑FIB milling, and other approaches.
• Demonstrated ability to effectively communicate and establish relationships with colleagues and collaborators in both oral and written forms.
• Demonstrated ability to train or teach effectively.

• Experience in computational analysis of microscopy and/or Cryo-EM data.
• Basic familiarity with both tomographic and single‑particle Cryo‑EM methods.
• Experience in correlating images or data from multiple instruments to target a region of interest or enhance total analysis of the sample under study.

Master’s Degree or PhD in Biophysics, Chemistry, Biochemistry, Molecular Biology, Structural Biology, or a related field.

The University of Wisconsin-Madison is an Equal Opportunity Employer. Qualified applicants receive consideration for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, pregnancy, disability, veteran status, or any other bases as defined by federal regulations and UW System policies.