Scientist III, Process Chemistry; Antibody-siRNA Conjugates

Responsibilities

• Optimize discovery-stage conjugation protocols for antibody‑siRNA conjugates to improve yield, reproducibility, and product quality.
• Develop GMP‑ready, kilogram‑scale conjugation processes, including site‑specific and stochastic conjugation strategies, linker chemistry, and payload attachment.
• Perform hands‑on conjugation reactions, purification (chromatography, TFF/UF‑DF), and analytical control strategy development.
• Oversee CROs/CDMOs: set technical direction, review data, and ensure timelines and quality standards.
• Characterize conjugates for DAR/siRNA‑to‑antibody ratio, aggregation, charge heterogeneity, and stability (e.g., HIC, SEC, IEX, LC‑MS, AEX).
• Lead technology transfer to internal/external manufacturing partners; author process descriptions, batch records, and development reports.
• Troubleshoot process/analytical issues; design experiments to define process parameters, ranges, and robustness for kilogram‑scale operation.
• Collaborate cross‑functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams.

• PhD in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or related field; or BS/MS with commensurate hands‑on industry experience.
• Demonstrated hands‑on experience in siRNA conjugation development.
• Working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods.
• Familiarity with purification and analytical characterization of conjugates.
• Strong problem‑solving, documentation, and communication skills.

• Experience with AOCs or ADCs.
• Experience scaling processes to GMP/kilogram scale and managing CRO/CDMO relationships.
• Knowledge of site‑specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry).
• Experience with tech transfer and CMC/GMP environments.

Competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.