Senior Scientist , DMPK

Responsibilities:

• Develop and implement in vitro and in vivo DMPK strategies to support preclinical development across multiple indications and routes of administration.
• Manage DMPK activities, including oversight of internal resources and CRO partners, to ensure high-quality, timely data delivery.
• Design, supervise, and execute preclinical PK studies, including non-compartmental analysis (NCA); interpret data; report; communicate PK/PD insights.
• Prepare and deliver IND-enabling DMPK packages, ensuring compliance with regulatory expectations and contributing to regulatory submissions.
• Apply GLP/GCP principles and ensure appropriate documentation for regulated studies.
• Support GLP toxicokinetic (TK) study design, analysis, and reporting.
• Oversee metabolite identification in preclinical and clinical samples using high-resolution mass spectrometry (HRMS).
• Provide scientific leadership, troubleshooting, and cross-functional collaboration.
• Maintain current knowledge of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics.

• PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical Sciences, or related discipline; at least 3 years of industry experience.
• Deep DMPK expertise; working knowledge of nucleotide/oligonucleotide drug metabolism and distribution (highly desired).
• Hands-on experience with in vitro ADME assays, in vivo PK studies, DDI evaluations, and Phoenix Win Nonlin.
• LC-MS/MS and HRMS experience, ideally for oligonucleotide therapeutics.
• Strong background in organic chemistry, biochemistry, and drug biotransformation.
• Demonstrated drug development experience and understanding of regulatory processes.
• Excellent communication skills; ability to interpret and present complex scientific data clearly.

• Wisconsin pay range: $115,000 USD - $140,000 USD.
• Competitive salaries and an excellent benefits package.