Senior Scientist - CMC

Empirico, a clinical-stage biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA medicines is seeking a chemist with an interest in solid-phase oligonucleotide synthesis and analytics. This is an excellent opportunity for a highly motivated, creative scientist to be a vital member of our team.

• You will be responsible for supporting the synthesis, purification, and characterization of oligonucleotides and their conjugates, and optimizing methodologies to support the development of siRNA medicines. The ideal candidate will have experience in organic and analytical chemistry and both upstream and downstream oligonucleotide manufacturing processes. A key focus of this role will be developing scalable processes suitable for technology transfer to CDMOs.
  
  You will be expected to –
• Perform solid-phase synthesis, purification, and characterization of oligonucleotides
• Develop and optimize scalable upstream (synthesis) and downstream (purification, formulation) manufacturing processes
• Support process development activities to enable successful technology transfer to CDMOs
• Analyze, interpret, and clearly communicate synthetic and analytical data
• Present findings to senior staff and cross-functional teams
• Troubleshoot and refine synthesis and purification protocols
• Manage multiple projects simultaneously in a fast paced environment
• Support GLP related activities and IND-enabling process development efforts

• This position requires a BS in Chemistry with at least 12 years of relevant industry experience, or an MS in Organic Chemistry, Biochemistry, or Chemical Engineering with at least 7 years of relevant experience, or a PhD with at least 3 years of relevant experience.
• Industry experience in solid-phase oligonucleotide synthesis is preferred, as well as familiarity with both upstream and downstream oligonucleotide manufacturing processes
• Minimum 1 year of experience working in a cGMP environment with demonstrated understanding of cGMP principles
• Hands-on proficiency with analytical instrumentation such as NMR, LC-MS, and RP-HPLC
• Demonstrated ability in analytical and purification method development using RPIP-HPLC, AEX-HPLC, UV, MALDI, and HRMS
• Background in process development and technology transfer to CDMOs, including development of scalable purification and formulation methodologies
• Working knowledge of tangential flow filtration (TFF) method development
• Experience supporting GLP studies and familiarity with regulatory expectations for IND-enabling work
• Experience with lyophilization and aseptic fill/finish operations
• Applicants must have authorization to work in the U.S.

The estimated annual base salary range for this role is $110,000 to $160,000. Individual compensation decisions will be based on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. We offer a wide range of benefits including a retirement savings plan (with company match), paid vacation, holidays, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Empirico is a clinical-stage biotechnology company that discovers and develops siRNA medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease. Empirico’s two foundational and proprietary technology platforms - the Precision Insights Platform™ for genetically-validated target discovery, and the siRCH™ platform for the discovery and development of siRNA medicines - enable Empirico and its collaborators to rapidly advance programs from the discovery and validation of novel targets to clinically-viable therapeutics Empirico’s exceptional internal capabilities, augmented by those of its partners, are driving the advancement of a growing and differentiated pipeline of wholly-owned and partnered programs for a broad range of common diseases with unmet medical need.

Empirico is headquartered in San Diego, CA with a major second R&D site…