Postdoctoral Associate | Bennett Lab

Postdoctoral Associate
Bennett Lab
The Jackson Laboratory
Bar Harbor, ME.

The Bennett Lab is dedicated to uncovering the fundamental mechanisms that govern the developmental emergence of hematopoietic stem cells (HSCs) and translating these insights toward improved stem cell engineering for regenerative medicine.

The laboratory focuses on understanding HSC specification and maturation
in embryonic development by:

• defining how TGF-β/BMP signaling regulate the transition from pre-HSCs to transplantable HSCs, including the role of SMAD7 and related downstream effectors.
• the identification of novel regulators to this process and defining how rare pre-hematopoietic stem cell intermediates arise from hemogenic endothelium and mature into fully functional, multi-lineage engraftable HSCs.

Our long-term goal is to identify the precise molecular signals that enable robust HSC formation and use this knowledge to improve the efficiency of producing of transplantable HSCs for therapeutic purposes.

The Bennett lab uses a multidisciplinary approach integrating mouse genetics, embryo models, transplantation assays, flow cytometry, confocal microscopy, clonal barcoding, and single-cell genomics. The lab offers a highly collaborative environment with opportunities to work across programs at The Jackson Laboratory as well as with external collaborators in the field. Trainees will be supported in fellowship applications, publications, conference presentations, and career development toward academic or industry paths.

The successful candidate will be able to plan, develop, execute, and analyze an independent research project within the lab’s main focus areas. Potential projects may include mechanistic studies into how TGFb/BMP signaling pathways regulates pre-HSC maturation or mapping transcriptional states of developmental HSC emergence using single-cell and clonal barcoding approaches.

Additional responsibilities include preparing manuscripts, fellowship applications, and conference presentations, as well as mentoring junior lab members and contributing to a collaborative team environment.

• Ph.D., M.D., or equivalent degree in biological sciences or related discipline
• Minimum of one first-author publication from graduate studies or prior postdoctoral work
• Strong foundational training in molecular biology, cell biology, developmental biology, or stem cell biology
• Excellent verbal and written communication skills
• Self-motivated and able to work independently as well as collaboratively

• Hematopoiesis, stem cell biology, developmental biology, or vascular biology
• Mouse models, transplantation assays, or in vivo lineage tracing
• Flow cytometry, cell sorting, and primary cell culture
• Single-cell RNA-seq, ATAC-seq, spatial genomics, or related genomic technologies
• Lentiviral systems or clonal barcoding
• Computational biology, bioinformatics, or quantitative data analysis

• Year 0 - 1: $65,589
• Year 1 - 2: $67,318
• Year 2 - 3: $69,095
• Year 3 - 4: $70,521
• Year 4 - 5: $72,877
• Year 5 - 6: $75,569

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community.

For more information, please visit (Use the "Apply for this Job" box below). .

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.