Senior Statistician, Center Vaccine Innovation and Access

PATH is a global nonprofit dedicated to achieving health equity. With more than 40 years of experience forging multisector partnerships and with expertise in science, economics, technology, advocacy, and dozens of other specialties, PATH develops and scales up innovative solutions to the world's most pressing health challenges.

PATH's Center for Vaccine Innovation and Access (CVIA) brings together our expertise across every stage of the long and complex process of vaccine research, development, and delivery to make lifesaving vaccines widely available to children and communities across the world. CVIA's current portfolio encompasses more than two dozen vaccines either in development or already in use to protect against fifteen different diseases.

Our focus is on vaccines to address the leading diseases that claim children's lives worldwide: pneumonia, diarrheal disease, and malaria; as well as other global health priorities, such as polio and meningitis. We work in partnership with national health ministries, pharmaceutical manufacturers, donors, international financing and regulatory organizations, and many others. PATH has led numerous global partnerships, including the award-winning Meningitis Vaccine Project and the Malaria Vaccine Initiative, which helped develop the first malaria vaccine candidate recommended for pilot implementation.

PATH is seeking a Senior Statistician who is an experienced clinical trial biostatistician to support the design, planning, execution, and analysis of Phase 1, 2, and 3 vaccine clinical trials, with an initial focus on oral polio vaccine studies. Within CVIA, the polio program supports the global polio eradication effort through a broad portfolio of clinical, epidemiological, and diagnostic work, including clinical development of novel oral polio vaccines (nOPVs), with projects spanning early-phase safety and immunogenicity studies through large Phase 3 international clinical trials.

The Senior Statistician's initial focus will be on the clinical development of nOPVs, including two Phase 3 trials currently in design stage, with opportunities to contribute to other CVIA vaccine development programs as needed.

Reporting to the Director of Statistics and Data Management, under the leadership of the Global Head of Clinical, statisticians on the clinical team support CVIA programs by overseeing CROs; contributing to protocol design; developing statistical analysis plans; analyzing trial data; drafting and reviewing clinical study reports and manuscripts; and providing statistical consultation on the design and analysis of clinical trials and epidemiological studies.

This role requires both hands‑on statistical leadership and effective oversight of external partners, with responsibilities spanning protocol design, analysis planning, clinical study reporting, regulatory support, and scientific communication.

• Serve as a study statistician for Phase 1, 2, and 3 clinical trials of oral polio vaccines (OPVs, nOPVs), conducting, supporting, and overseeing all statistical activities across all phases of these studies.
• Lead or contribute to the statistical design of OPV/nOPV trials, including sample size and power calculations, randomization schedules, interim/futility analyses, and Data and Safety Monitoring Board (DSMB) support.
• Develop or review statistical analysis plans and analyze and interpret data from OPV trials (e.g., immunogenicity, shedding, and safety endpoints), providing input to study reports and manuscripts with emphasis on the statistical methods section.

• Provide statistical support to CVIA's broader clinical development programs to ensure that scientifically valid conclusions are drawn concerning claims with…