Principal Scientist - LCMS Bioanalysis

Principal Scientist I – Marlborough, MA About the Opportunity

Meadowhawk Biolabs is seeking an enthusiastic and highly motivated Principal Scientist to work within the Discovery Bioanalytical Team at our Marlborough, MA site. The ideal candidate is creative, hardworking, results focused, driven and has extensive prior experience in LC-MS/MS analysis of biologically derived samples. Given that we are a newly launched Contract Research Organization (CRO) founded by an experienced team of industry veterans, this senior scientific position offers unique ground floor opportunities for the successful candidate to contribute meaningfully to the creation and development of our services, expand their knowledge base by participation in multidisciplinary teams, and advance their career in capabilities and responsibilities.

• Develop, conduct, and troubleshoot bioanalytical LC-MS/MS methods of varying complexity
• Serve as primary point of contact with clients for discovery bioanalytical projects - responsible for managing study logistics, keeping sponsors informed of study progress, and delivering quality data under strict timelines
• Manage daily activities for a team of scientists including assigning priorities and overseeing execution of experiments to ensure timely delivery of robust bioanalytical data to clients
• Provide technical training and mentoring to junior staff to foster their career growth
• Work closely and collaboratively with the business development group to establish new clients and maintain/grow existing client relationships
• Independently develop innovative solutions to solve challenging study objectives
• Evaluate and implement novel scientific approaches, technologies, or tools
• Spearhead the creation, revision, and review of SOPs and guidelines as appropriate
• Identify and lead operational process improvement initiatives
• Perform all other related duties as assigned

Bachelor’s or Master’s degree in chemistry, biochemistry, pharmaceutical sciences, or another related scientific field with a minimum of 8 years (BS) or 6 years (MS) directly related industry experience. Doctorate degree with at least 2 years of experience preferred. Equivalent combination of education, training, and experience will be considered as substitution for the specific requirements outlined above.

• Full competency in all aspects of bioanalysis by LC-MS/MS including method development, execution of quantitative assays, critical review of data, and communication of scientific results
• Fluency in the use, troubleshooting, and maintenance of UPLC systems and triple quadrupole mass spectrometers
• Subject matter expert in sample processing techniques for extraction of small molecule therapeutics and endogenous compounds from biological matrices
• Experience in quantitation of large molecules by LC-MS (proteins, ADCs, oligonucleotides) a plus
• Demonstrated success in the development or deployment of new technologies or processes
• Ability to thrive in a fast-paced, collaborative team environment while remaining innovative, flexible, resourceful, and efficient
• Highly organized and detail-oriented in data recording and review
• Excellent interpersonal, written, and verbal communication skills
• Previous experience mentoring junior staff required
• Proficiency in Microsoft Office required (Excel, Word, PowerPoint); prior experience working with laboratory information systems (LIMS/ELN) to manage sample tracking and analysis is preferred.

In addition to the attributes described above, the ideal candidate will be highly collaborative, open-minded, self-aware, flexible, data-driven and objective in its evaluation, persistent and optimistic in the face of challenges and uncertainty, and willing to make decisions and take ownership for assigned responsibilities.

The target base salary for this position is between $96,000 - $127,000 per year. The specific rate for this position may vary and will be based upon factors including, but not limited to the individual’s experience, education, and skills. In addition to wages, Meadowhawk Biolabs provides a full benefits package upon…