Research Intern; Downstream Processing - Onsite Marlborough, MA

Position: Research Intern (Downstream Processing) - Onsite Marlborough, MA
## Research Intern (Downstream Processing) - Onsite Marlborough, MAApplylocations:
Marlborough, MA, United States of America time type:
Full time posted on:
Posted Todayjob requisition :
R40595

We are seeking a motivated and technically skilled intern (PhD level) to support research and development activities in downstream processing of extracellular vesicles (EVs) and viral vectors. The successful candidate will work closely with a multidisciplinary team to optimize and execute purification workflows using tangential flow filtration (TFF) and chromatography-based methods. This internship provides hands-on experience in biologics processing and analytical evaluation, contributing directly to process development for therapeutic nanoparticles.
** Hands on position starting September 2025 for a minimum of six months up to a maximum of ten months
**** Onsite at our Marlborough, MA site,
** In the Research Intern role, you will serve as a critical contributor to the development and integration of Sartorius’ emerging technologies for characterization and purification of different types of nanoparticles such as extracellular vesicles and viral vectors. These leading-edge platforms will be utilized in basic research as well as the pharmaceutical and biotechnology industries.
** What you will accomplish together with us**
* ** Execute Purification Protocols**:
Perform purification of EVs and viral vectors using TFF systems (hollow fiber and/or flat sheet) and various chromatography modalities (e.g., ion exchange, size exclusion, affinity).

** Optimize Unit Operations**:
Assist in the design and optimization of downstream steps to improve product
** yield**,
** purity**, and
** scalability**.  
** System Operation and Maintenance**:
Operate and maintain TFF and chromatography systems (e.g., AKTA or equivalent), including set-up, cleaning, and troubleshooting.  
** Sample Handling and Quantification**:
Prepare and process samples following SOPs. Quantify particles using orthogonal methods such as NTA, qPCR, protein assays, and total RNA analysis.  
** Process Monitoring and Data Recording**:
Monitor and document key parameters (e.g., transmembrane pressure, flux, recovery) during TFF runs. Maintain detailed lab notebooks and process logs.  
** Analytical Support**:
Support integration of downstream data with analytical assays (e.g., flow cytometry, SEC-MALS, SDS-PAGE) for process characterization.  
** Collaborative Work**:
Interact regularly with upstream, analytical, and formulation teams to align on process goals and transfer knowledge.  
** Safety and Compliance**:
Follow laboratory safety protocols and ensure compliance with quality standards and experimental reproducibility.
** What will convince us
*
* Education:

* PhD candidate in Bioengineering, or closely related discipline with formal education and experience with extracellular vesicles characterization and purification.

Experience:

* ** Hands-on experience with TFF systems** (lab or pilot scale) for nanoparticle or biologics concentration and diafiltration.  Practical knowledge of
** chromatography techniques
** such as SEC, IEX, or affinity purification.  Familiarity with
** nanoparticle systems
** such as EVs, viral vectors (e.g., AAV, lentivirus), or LNPs.  Comfortable working in a wet lab environment with complex biological samples.  Strong documentation and organizational skills; experience with SOPs and batch records is a plus.  

Experience with analytical tools (e.g., NTA, BCA, qPCR, HPLC, or SEC-MALS) is highly desirable
* Identification with our core values:
Sustainability, Openness, Enjoyment Compensation is up to $30 hr.
** What We Offer
** As a growing global life science company, with our stock listed on the German DAX and TecDAX , Sartorius offers a wide range of benefits:  
** Personal and Professional Development:
** Mentoring, leadership programs, internal seminar offerings  
** Making an Impact Right from the Start:
** Comprehensive onboarding, including a virtual online platform  
** Welcoming Culture:
** Mutual support, team spirit and international collaboration; communities on numerous topics such as “Coaching”, “Agile Working” and a “Businesswomen’s…