Protein Analytical Scientist – Mass Spectrometry (Large Molecules

Global Bioproduction Analytics Team Member

Do you have a passion for innovative ideas and groundbreaking discoveries? With over $1 billion invested annually in R&D, at Thermo Fisher Scientific you'll help solve some of the world's toughest challenges, from giving cancer patients hope, ensuring safe drinking water and helping law enforcement tackle cases through forensics. We empower our teams to put science into meaningful action and give our R&D colleagues the autonomy, resources, and tools they need to take science a step beyond.

Location:

On-site Hunt Valley, MD. Relocation assistance is NOT provided.

Discover impactful work:

We are looking for a motivated individual to join our Global Bioproduction Analytics Team. This position supports a cross-functional team working toward the design and commercialization of new cell culture media and media supplement products. The successful candidate will have extensive experience with high-resolution LC-MS workflows for large molecules, including monoclonal antibodies (mAbs), bispecific antibodies (bsAbs), antibody-drug conjugates (ADCs), and other therapeutic proteins.

This role requires strong analytical problem-solving skills, the ability to interpret complex datasets, and close collaboration with cross-functional teams to deliver high-quality analytical solutions that accelerate cell culture media development.

What you will do:

• Develop, optimize, and execute LC-MS methods for the characterization of therapeutic proteins using high-resolution mass spectrometry platforms.
• Analyze and interpret complex mass spectrometry datasets to identify and characterize post-translational modifications (PTMs), sequence variants, chain mispairing, and structural attributes of monoclonal antibodies, bispecific antibodies, ADCs, and other protein therapeutics.
• Characterize critical quality attributes (CQAs), including glycan heterogeneity, charge variants, aggregation, and molecular integrity using orthogonal analytical techniques.
• Perform intact mass analysis, middle-down characterization, peptide mapping, and other large molecule MS-based workflows.
• Prepare clear, accurate, and scientifically sound reports, technical presentations, and analytical documentation for internal and external stakeholders.
• Troubleshoot analytical methods, investigate unexpected results, and recommend scientifically justified solutions.
• Perform routine testing, maintenance, troubleshooting, and performance verification of mass spectrometers, liquid chromatography systems, and associated instrumentation to ensure reliable operation.
• Stay up-to-date with the latest technological and practical advancements in the field of analytical chemistry as they pertain to cellular processes.

Minimum qualifications:

• Ph.D. in Analytical Chemistry, Biochemistry, Chemistry, Pharmaceutical Sciences, or a related scientific discipline with 0–3 years of relevant experience; or M.S. with 3+ years; or B.S. with 6+ years of relevant industry experience.

Preferred qualifications:

• Strong background in analytical chemistry, protein biochemistry, or biopharmaceutical characterization.
• Hands-on experience operating high-resolution mass spectrometry platforms (e.g., Orbitrap or equivalent).
• Demonstrated expertise in LC-MS method development and optimization for large molecule characterization. Experience with MAM and iMAM workflows is a plus.
• Experience with intact mass analysis, middle-down workflows, peptide mapping, and disulfide bond characterization is a plus.
• Proven experience characterizing monoclonal antibodies, bispecific antibodies, antibody fragments, antibody-drug conjugates, or related therapeutic proteins.
• Knowledge of protein post-translational modifications, glycosylation analysis, charge variant analysis, aggregation analysis, and higher-order structure characterization.
• Experience using data analysis software for mass spectrometry interpretation and reporting.
• Excellent troubleshooting, critical thinking, and problem-solving skills.
• Strong written and verbal communication skills with the ability to present complex analytical data to diverse audiences.
• Ability to manage multiple projects in a…