Senior Manager, Operational Excellence, Cell Therapy

Senior Manager, Operational Excellence, Cell Therapy

The Senior Manager, Operational Excellence, Cell Therapy is responsible for applying lean/six sigma techniques to improve end‑to‑end operations and supply chain processes that deliver best‑in‑class safety, quality, productivity and cost across the Cell Therapy value streams. This role requires a strong understanding of the Toyota Production System, Hoshin Kanri implementation, value stream and process mapping, and KPI monitoring.

M–F, Standard Working Hours

• Build the Operational Excellence Structure and Governance for the Devens Facility.
• Develop Policy Deployment (Hoshin Kanri), Value Stream Maps, Visual Management Systems and other key lean tools.
• Grow the Operations Excellence maturity level in the organization.
• Analyze and identify process improvement opportunities and partner with key stakeholders to scope and ensure alignment with strategic priorities.
• Evaluate and establish processes and systems with the goal of improving product quality, throughput, capacity, reducing costs and lead times.
• Utilize business intelligence tools (e.g., Tableau) and advanced analytics to improve key performance metrics and achieve desired operational capability and growth.
• Utilize simulation software (e.g., Arena, Promodel) to create models to identify resources needed to support operations.
• Identify required resources including personnel, tooling, equipment, facilities, work‑in‑process and production.
• Create and maintain capacity models, simulation models, and proactively drive capacity solutions.
• Establish work measurement programs and analyze work samples to develop labor standards.
• Analyze workforce utilization, facility layout, and operational data such as production costs, process flow, headcount and schedules.
• Support project teams, prepare project schedules, coordinate execution of technical projects and develop presentations to disseminate results to stakeholders and senior management.
• Implement methods for improving efficiency and reducing waste of raw materials and utilities.
• Design and facilitate Kaizen workshops to understand current processes and design future state plans.
• Conduct Gemba‑style process documentation and diagnostic activities.
• Collect, consolidate, and analyze data and information, presenting it in a format that supports effective decision making.
• Work across all levels to identify business impacts and support the development of change plans.
• Participate in team meetings and contribute to the development of Process Excellence tools and methods.
• Run internal projects (e.g. project initiation, planning, scope, funding requests, approvals, execution and closeout).
• Direct multidisciplinary project teams to ensure delivery on time, on budget and to pre‑defined quality levels.
• Work closely with Engineering and Maintenance on design and implementation of new technology and facilities related to production process needs.
• Foster strong inter‑team relationships to achieve common project goals.
• Support monitoring, analyzing, and optimizing the end‑to‑end process and mitigate issues that arise during production.
• Provide investigation support for production related investigations, ensuring compliance with internal and regulatory requirements.
• Design and execute test plans and risk mitigation exercises as part of investigations (e.g., root cause analysis and CAPAs).
• Support inspection readiness and actively support regulatory inspections and ensure safe and compliant cGMP operations.
• Review and revise the content of technical documentation (investigations, changes, SOPs, batch records).
• Support the tracking of team metrics and manage completion of objectives and projects.
• Drive changes across the organization.

• Promote a mindset of continuous improvement, problem solving, and prevention.
• Create an environment of teamwork, open communication, and a sense of urgency.
• Support the change agent in promoting flexibility, creativity, and accountability.
• Support organizational strategic goals linked to the overall company strategy.
• Drive strong collaboration within the plant and across the network.
• Build trust and effective relationships…