Lead Researcher- Bone Marrow Transplantation and Cellular Therapy

The Department of Bone Marrow Transplantation and Cellular Therapy (BMTCT) is seeking a talented and highly motivated Lead Researcher to conduct experiments under the overall direction of the Director of the Immune Monitoring Core (IMC). The IMC plays a central role in the department’s translational research program by performing molecular and functional immune monitoring for clinical studies in hematopoietic stem cell transplantation, as well as cell and gene therapies, including CAR T cell therapy.

The successful candidate will independently conduct experiments, contribute to the development of novel assays, troubleshoot technical challenges, manage advanced instrumentation, accurately document experimental procedures and data, and collaborate closely with investigators and staff within and beyond the BMTCT department.

• Process clinical samples, including isolation of peripheral blood mononuclear cells (PBMCs).
• Perform molecular and cellular assays, including DNA/RNA extraction, ELISpot, qPCR/dPCR, and cytokine/chemokine analyses.
• Maintain accurate, thorough, and compliant documentation of experimental procedures, results, and data analyses.
• Operate and maintain advanced laboratory platforms, including Quant Studio 6/7, ABI 3500, Luminex FlexMap3D, QIAcuity4 Digital PCR, Qiagility liquid handler, Olink SignatureQ
  100, and Maxwell
  
  RSC systems.
• Train laboratory personnel on instrument operation, data quality standards, and best practices.
• Support equipment maintenance, quality control tracking, LIMS documentation, SOP development and revisions, and inventory management.
• Contribute to the development, optimization, and validation of immune monitoring assays to support departmental clinical trials.
• Design and conduct experiments, analyze data, and prepare scientific reports and presentations.
• Troubleshoot assay performance issues and refine workflows to improve efficiency and data quality.

• Hands‑on experience with qPCR and/or dPCR, and strong proficiency in aseptic laboratory techniques.
• Experience with RNA and DNA isolation, cytokine assays, and PBMC preparation.
• Strong communication, organizational (including data management), and analytical troubleshooting skills.
• Demonstrated ability to manage multiple concurrent priorities and rapidly learn new laboratory techniques.

Bachelor’s degree in a relevant scientific area is required.

• 5+ years of research experience is required.
• 3+ years of experience is required with a Master’s degree.
• No prior experience required with a PhD.
• Strong knowledge and experience in understanding and application of underlying principles related to techniques being performed.
• Experience in R&D methods and processes in lab setting, and execution of research projects for the laboratory preferred.
• Proven performance in earlier role/comparable role.

A reasonable estimate of the current salary range is $60,320 - $105,040 per year for the role of Lead Researcher in Bone Marrow Transplantation and Cellular Therapy.

St. Jude is an Equal Opportunity Employer.