Postdoctoral Research Associate - Structural Biology
Listed on 2026-06-02
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Research/Development
Research Scientist, Postdoctoral Research Fellow
Position Overview
A postdoctoral research associate position is available in the lab of Tanja Mittag in the Department of Structural Biology. Project
Description:
The Mittag lab invites applications for a Postdoctoral Research Fellow to work on structures of the tumor suppressor and ubiquitin ligase component SPOP. We have recently solved the first cryo‑EM structures of full-length SPOP (Cuneo et al. Mol Cell 2023), and they have revealed interfaces that had not recently been observed in structures of smaller constructs. Importantly, these interfaces are lined with cancer mutations whose molecular mechanisms were not previously understood, but now provide molecular explanations for pathophysiological mechanisms.
We have also revealed that certain mutations lead to large changes in qua ternary assembly. The project provides opportunities for characterizing structures of SPOP complexes with additional ligase subunits and of disease mutants with altered structures. The implications of these structural changes will be characterized via in vitro biochemical and in cell functional assays.
The successful candidate will help shape the direction of the research and use cryo‑EM and in‑vitro biophysical and biochemical studies to characterize SPOP structure and function. The candidate will interface with trainees and staff scientists in the Mittag lab and with collaborators in a highly collaborative, interdisciplinary environment that will support their career development.
Minimum Education and/or Training- Ph.D. in in vitro structural biology, protein biochemistry or biophysics.
- Demonstrated academic record of excellence and strong interest in the growing field of biomolecular condensates.
- Experience with cryo‑EM would be highly valuable.
- Competitive salary starting at $72,500 per year.
- Comprehensive benefits and generous relocation assistance.
St. Jude is an Equal Opportunity Employer. St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities.
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