Director Hartwell Center Biotechnology Shared Resource

e Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world‑class facilities, state‑of‑the‑art technologies, and exceptional support for our researchers to ensure scientific progress is never halted due to a lack of resources. e, you will be part of a collaborative, bench‑to‑bedside environment where you can directly witness how our science translates into survival for the children we serve.

We are seeking a dynamic Director with advanced expertise in cutting‑edge genomics and genome sequencing technologies to lead the Hartwell Center for Biotechnology Shared Resource. The Hartwell Center is a major core research facility e that provides advanced genome technologies to scientists studying pediatric catastrophic diseases, and is a driver of innovation and research excellence. In 2025, the Center processed over 46,000 samples collected from 135 labs and generated approximately 1.35 Pb of Illumina short‑read and 11 Tb of Pac Bio long‑read data.

This effort contributed to 122 publications in 2025, including four co‑authored by Hartwell staff members. In addition, the Hartwell Center incorporates functional genomics and peptide synthesis. It also provides computational support for base calling and alignment. The director will oversee 20 multidisciplinary team members distributed across 6 domains:
Illumina, Pac Bio, Genotyping, Functional/Arrays, RNA, and Peptide Synthesis.

The successful candidate will lead this team of researchers and scientists supporting the research laboratories e Children’s Research Hospital with a clear vision to fulfill our mission to improve the treatment and care of children with catastrophic diseases. The director will work with staff to create clearly defined roles that foster engagement and allow for appropriate career advancement. The director will maintain extensive and up‑to‑date knowledge of genomics and genome sequencing platforms and emerging applications to sustain and evolve a cutting‑edge research facility.

In this role, the successful candidate will employ and maintain effective communication with investigators, shared resource staff, and other personnel involved in relevant projects and activities. The director will implement systems to routinely assess quality, consistency, and opportunities for innovation. The director will advise and interact with faculty and other research staff and trainees on the management, design, technical needs, and execution of projects served by the Hartwell Center for Biotechnology.

The successful candidate will oversee operations and quality of the services provided by the shared resource and develop annual budgets and recommendations for future capital acquisitions and growth.

The Hartwell Center for Biotechnology Shared Resource is housed within our state‑of‑the‑art Shared Resource Center building in approximately 6,500 sq. ft. of space encompassing dedicated office, workstation, wet‑lab and instrumentation spaces.

Genome Sequencing Facility:

Supported by four Illumina Nova Seq X Plus genome‑scale production systems, one Next Seq 2000 mid‑range sequencer, three MiSeq i100 Plus sequencers, two MiSeq sequencers, and one iSeq 100 benchtop system. Long‑read sequencing workflows are supported by two Pac Bio Revio systems. Genomic workflows are also supported by multiple liquid‑handling robots and QA instruments to ensure consistent high‑quality analysis of over 30,000 samples per year.

Genotyping:

Supported by a Perkin Elmer Janus liquid‑handling robotics system, 11 Applied Biosystems Veriti thermal cyclers for sample preparation and an Applied Biosystems 3500xl DNA Analyzer.

Microarray:

Hosts a variety of equipment including an Illumina iScan system equipped with an array loading robot plus three complete Affymetrix Gene Chip cartridge analysis systems comprising three Gene Chip 640 hybridization ovens, eight automated Gene Chip 450 fluidics wash stations, and three high‑resolution (7G) Affymetrix Gene Chip 3000 scanners each with 48‑place autoloaders, one HiScan bead array scanner with autoloader, and a Tecan Evo…