Director of Scientific Research, Single-molecule Imaging Center

The Department of Structural Biology at St Jude Children's Research Hospital is seeking to hire a Director of the Single‑Molecule Imaging Center (SMC) to lead an interdisciplinary team, whose backgrounds span computer science, engineering, applied math, biophysics and biology, to advance the frontiers of single‑molecule research while also implementing focused strategies to work with non‑experts seeking to incorporate single‑molecule methods into their discovery pipeline.

e Children's Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide world‑class facilities. State‑of‑the‑art technologies. Extraordinary support. And a collaborative, bench‑to‑bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, e, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.

The ideal candidate has extensive experience developing and utilizing single‑molecule fluorescence microscopy methods to reveal new insights in biology and/or medicine and sufficient technical background to design and implement hardware and software solutions that facilitate instrument stability, experimental throughput and Center accessibility as well as teach and disseminate knowledge to non‑experts.

The mission of the SMC e is to push the frontiers of single‑molecule methods development across multiple modalities, while making these technologies accessible to a broad user base of biology‑focused scientists within the department of Structural Biology, and across the Institution and its affiliates.

The SMC is integrated into a community of institutionally‑funded laboratories and innovation centers e, each with their own dedicated staff, including the Cryo‑EM Center, the Protein Technology Center, the Cell and Tissue Imaging Center, The Center for Bioimage Informatics, The Center for Applied Bioinformatics, the Center of Excellence for Data‑driven Discovery and the Center for Advanced Genome Engineering (CAGE).

The SMC houses a variety of cutting‑edge single‑molecule instruments, both in vitro and in living cells, with a mission to utilize these technologies for high‑impact projects that advance the understanding and treatment of catastrophic childhood diseases, including infectious diseases and cancers. This includes instruments for confocal time‑correlated single‑photon counting (Pico Quant MT200), spinning disk confocal, objective‑based TIRF, prism‑based TIRF, combined fluorescence and optical trap (Lumicks C‑Trap), and DNA curtain measurements.

While some instruments have commercial foundations, most have been customized, or home‑built, to maximize data quality, throughput, time resolution, and ease of use by non‑experts. To facilitate engagement and the data collection‑to‑publication processes, the SMC maintains bespoke software tools for instrument control, data acquisition (FLASH), and data analysis (SPARTAN) softwares, which are disseminated for widespread use by the single‑molecule community.

The SMC is integrated with other resources e that provide access to 3D printers, laser engravers, an on‑site machine shop for creating custom‑engineered microscope hardware, high‑performance computing resources for software development and data management, as well as technology infrastructures for surface chemistry and microfluidics.

Technologies within the SMC have enabled discoveries in a wide variety of biological systems, including the cystic fibrosis transmembrane receptor (CFTR), β‑arrestins, G‑protein coupled receptors (GPCRs), transporters, riboswitches, periplasmic amino acid binding proteins, bacterial/human ribosomes, whole viral particles, and more.

The successful candidate will continue this history of success by guiding collaborators to achieve single‑molecule resolution to a wide variety of clinically important biological systems.

• Direct Center activity on a day‑to‑day basis to ensure staff are efficiently tasked, instruments are properly functioning and correctly…