Senior Researcher in Protein Technologies Center

We are looking for a Senior Researcher to participate in our exciting studies of the human protein kinome.

This Associate Scientist position is part of the Blue Sky Initiative “Seeing the Invisible in Protein Kinases” e Children's Research Hospital in Memphis, TN. The Blue Sky Initiative is an interdisciplinary project in the Department of Structural Biology supported by $50 million in institutional funding. It leverages ultra-high field nuclear magnetic resonance (NMR), cryo‑electron microscopy, X‑ray crystallography, data science and computational approaches to characterize the conformational landscape of the human kinome.

Knowledge of kinase conformations is used to discover new biology of kinase function and regulation in cells, understand the structural and functional consequences of disease‑associated mutations, and identify novel therapeutic opportunities.

As a member of the Protein Technology Centre/Blue Sky team, the candidate will use molecular biology, biochemistry, and biophysical skills to study the molecular mechanisms and structures of protein kinases and their cellular regulatory functions. The candidate will assist in preparing high‑quality proteins from various expression systems such as bacteria, insect cells, and mammalian cells for structural studies of kinases using NMR, crystallography and cryo‑EM.

The work involves studying multiple kinases, performing appropriate background research, optimizing biochemical and biophysical assays, and structural characterizations. This research can lead to new mechanisms of kinase regulation and/or novel kinase‑mediated biology.

• Bachelor’s degree in a relevant scientific area is required.

• Two (2) years of research experience is required with a bachelor's degree.
• No prior experience is required with a Master’s degree.
• Working knowledge and understanding of underlying concepts and principles of experimental design.
• Experience with the most widely used techniques used in the home laboratory.
• Proven performance in earlier role/comparable role.

St. Jude is including a reasonable estimate of the compensation range for this role: $26.00 - $45.50 per hour for the role of Senior Researcher in Protein Technologies Center.

St. Jude is an Equal Opportunity Employer.