Postdoctoral Research Associate

The dos Santos Laboratory is seeking highly motivated postdoctoral fellows to join a dynamic and collaborative research program focused on defining epigenetic and non-genetic determinants of breast homeostasis and cancer risk. Our research uniquely centers on normal breast biology as a foundation for cancer prevention, integrating advanced mouse models, organoid systems, lineage tracing, and single-cell genomics to uncover how physiological life events reprogram mammary tissue and influence tumor initiation and therapeutic response.

Our previous work has uncovered key mechanisms linking systemic changes to tumor initiation, single cell signatures of models of breast normal and cancer development and identified epigenetic and immune pathways that suppress tumor development, such as pregnancy-induced reprogramming and BPTF-dependent regulation of hormone responsiveness.

Ongoing and future projects aim to define immune-mediated mechanisms of cancer prevention, elucidate stromal–epithelial crosstalk driving tumor initiation and progression, and understand how prior childhood cancer and its treatment reshape mammary tissue and influence breast cancer susceptibility.

The lab offers a highly interactive and collaborative environment with strong expertise in single-cell transcriptomics and epigenomics, mammary gland biology, cancer initiation, and organoid and in vivo modeling systems. We are committed to mentoring trainees and fostering independence, creativity, and career development.

• PhD degree in biology, cancer biology, immunology, genomics, or related fields
• Strong background in molecular and/or cellular biology
• Experience with mouse models, genomics, or computational analysis is a plus
• Demonstrated ability to work both independently and collaboratively

St. Jude is an Equal Opportunity Employer