Postdoctoral Research Associate - Therapeutic Genome Engineering

A postdoctoral fellowship is available in the laboratory of Dr. Jonathan Yen in the Division of Experimental Hematology.

We are seeking a highly motivated and talented Postdoctoral Research Fellow to join our cutting‑edge research team focused on developing lipid nanoparticle (LNP)-based therapeutic strategies for targeting hematopoietic stem cells (HSCs). The successful candidate will work in a collaborative and interdisciplinary environment to advance novel genome editor delivery technologies and improve therapeutic outcomes in hematological disorders.

• Design, synthesize, and characterize LNP formulations optimized for targeting HSCs.
• Optimize lipid composition, particle size, and surface modifications (e.g., antibody conjugation for HSC targeting).
• Perform dynamic light scattering (DLS), zeta potential, and Ribo Green RNA concentration analyses to characterize nanoparticles.

• Utilize molecular biology techniques such as PCR, qRT-PCR, flow cytometry, and imaging to assess LNP performance and HSC function.
• Conduct high‑throughput screening of LNP formulations to evaluate gene delivery efficiency and specificity.

• Work with hematopoietic stem cell models to assess LNP‑mediated gene delivery.
• If applicable, perform HSC isolation, transplantation, and functional assays in preclinical models.

• Develop novel strategies to enhance LNP targeting, uptake, and efficiency in HSCs.
• Address key barriers in genome editor delivery, including specificity, stability, and immune response.

• Work closely with a multidisciplinary team of researchers and clinicians to advance therapeutic applications.
• Contribute to manuscripts, presentations, and grant applications.
• Present findings at internal meetings and scientific conferences.

• PhD in Molecular Biology, Bioengineering, Material Science Engineering, Chemical and Biological Engineering, Pharmaceutical Sciences, or related field.

• Strong expertise in mRNA nanoparticle formulation and characterization, gene delivery systems, or lipid-based therapeutics.
• Experience with microfluidic-based LNP formulation.
• Proficiency in DLS, zeta potential analysis, and Ribo Green RNA quantification.
• Knowledge of conjugation chemistry for targeted delivery.
• Excellent analytical, organizational, and communication skills.
• Ability to work both independently and collaboratively in a research‑driven environment.

• Expertise in hematopoietic stem cell biology, bone marrow niche, or hematology is highly desirable.
• Experience with animal models, preclinical research, and HSC transplantation.
• Familiarity with genome editing technologies (CRISPR‑Cas9, base editing, prime editing) for therapeutic applications.
• Proficiency in molecular and cellular biology techniques, with an emphasis on gene editing and mRNA delivery.
• Experience with HPLC analysis and drug development is a plus.

• A Blend of Academic Freedom and Industrial Efficiency:
  Access to shared resources and facilities led by expert scientists, coupled with cutting‑edge technology, accelerates research productivity.
• Customized Professional and Career Growth:
  Experience specifically designed programs to enhance professional growth and career readiness empowering postdocs for success beyond their training. This includes access to grant writing workshops, individual development plans, teaching and mentoring opportunities, non‑research career advancement programs, professional development allowance, and so much more.
• Competitive Compensation:
  Embark on your journey with a competitive salary starting at $72,500 a year, comprehensive benefits and generous relocation assistance, reflecting our commitment to recognize and invest in talent.
• A Sense of Community:
  St. Jude fosters a vibrant postdoc community that supports a well‑balanced life. A dynamic environment promotes connections and camaraderie among postdocs from all backgrounds.

St. Jude is an Equal Opportunity Employer.