Associate Scientist Antibody Discovery

Overview

Join an excellent team of researchers dedicated to coming closer to the mission of St. Jude Children’s Research Hospital, that no child will die at the dawn of life. Antibody Discovery Collaborative Centre (ADCC) within the Department of Host Microbe Interactions e seeks a skilled and highly motivated candidate experienced in antibody discovery.

• Antibody discovery with a focus on display methods (phage, yeast, mammalian) and experience in building high‑diversity libraries from synthetic and animal repertoires.
• Integrate ML‑based approaches to sequence discovery and engineering with display methods.
• Design discovery workflows and deliver panels of lead candidates for programs.
• Apply in‑vitro display methods for sequence discovery and manage multiple antigen screening arms.
• Apply NGS methods to mine antibody pools for sequence discovery.
• Develop and optimize high‑throughput mammalian cell‑based production platforms for recombinant antibodies, antigens, and other biologics.
• Work closely with mAb discovery platforms to support molecular biology workflows; design and execute construct generation for antibody expression.
• Perform DNA preparations to generate high‑quality plasmid material for mammalian cell transfection.
• Establish scalable transient and stable expression workflows in CHO, HEK
  293, and other mammalian expression systems.
• Purify using AKTA chromatography systems.
• Analyze purified proteins with High‑Performance Liquid Chromatography Size Exclusion Chromatography (HPLC‑SEC).
• Conduct molecular assessment of early‑stage development candidates (polyreactivity ELISA, CE‑SDS, SEC‑MALS, DSF).
• Maintain accurate and timely ELN data.

• Minimum Education:
  
  Bachelor’s degree in a relevant scientific area.
• Minimum Experience:
  
  7+ years of research experience; 5+ years of research experience with a Master’s degree; 2+ years of research experience with a PhD.
• Experience leading and supporting research experiments preferred.
• Experience guiding and training other laboratory personnel preferred.
• Proven performance in an earlier role or comparable role.

St. Jude is providing a reasonable estimate of the compensation range for this role: $65,520 – $114,400 per year for the position of Associate Scientist, Antibody Discovery.

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. All resumes submitted by search firms without a valid written search agreement will result in no fee being paid if the candidate is hired.

St. Jude is an Equal Opportunity Employer.