Researcher - Developmental Neurobiology; Han Lab

Overview

The Han laboratory e Children’s Research Hospital is seeking a highly motivated Research Technologist with a strong interest in the mechanisms of brain development, brain tumors, or neurodevelopmental disorders. Humans have the largest neocortex relative to their brain size, and its folded surface is thought to be the root of our unique mental abilities. What cellular and molecular mechanisms drive the development and evolution of this remarkable structure?

How do disruptions in these mechanisms lead to neurodevelopmental disorders and brain tumors? We aim to answer these fundamental questions by investigating the neural progenitor cells that construct the brain during development.

To uncover the mechanisms regulating human neural progenitor cells, we developed the first stable and robust genetic mouse model, in which neural progenitors acquire the key features of human neural progenitors, driving the transformation of the small, smooth mouse cortex into an expanded, folded cortex. In addition to this unique and powerful animal model, we employ a broad range of approaches, including human pluripotent stem cells, brain organoids, genome editing, high-resolution imaging, single-cell sequencing, spatial transcriptomics, and proteomics.

The immediate research project will focus on characterizing novel cellular models of a pediatric brain tumor, which have been derived from patient samples and human pluripotent stem cells. The successful candidate will work in a highly collaborative environment to investigate the mechanisms that drive tumorigenesis and to develop therapeutic approaches that target those mechanisms.

• Perform laboratory experiments as directed using specific and prescribed techniques/protocols.
• Follow basic protocols, implementing experimental techniques prescribed by supervisor and providing basic troubleshooting where appropriate.
• Accurately record experimental procedures and data.
• May draft results/data for posters, presentations or publications.
• Operate lab equipment.
• Perform other related duties as assigned to meet the goals of the department and institution.
• Maintain regular and predictable attendance.

• Bachelor's degree in a relevant scientific area is required.
• No experience required.

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. The current salary range is $24.00 - $42.00 per hour for the role of Researcher – Developmental Neurobiology (Han Lab).

St. Jude is an Equal Opportunity Employer.