Postdoctoral Research Associate - Hematology

Project Description

Hematopoietic stem cells (HSCs) sustain lifelong blood production, and defects in their regulation contribute to diverse hematologic disorders, including clonal hematopoiesis, hematologic malignancies, and aplastic anemia. This project aims to define how T cell‑mediated immune surveillance regulates HSC fate in the bone marrow and influences disease outcomes, ranging from immune tolerance and clonal expansion to graft‑versus‑leukemia activity and bone marrow failure.

Using state‑of‑the‑art mouse models, immunologic approaches, and single‑cell technologies, the successful candidate will investigate the cellular and molecular mechanisms that govern immune‑stem cell interactions. These studies will provide fundamental insights into hematopoietic homeostasis and uncover new therapeutic opportunities for hematologic disease.

• Conduct independent research on T cell‑mediated regulation of hematopoietic stem cells and bone marrow immunity.
• Design and perform experiments using mouse models, flow cytometry, molecular biology, and immunological approaches.
• Apply single‑cell and other advanced technologies to investigate immune‑stem cell interactions and hematologic disease mechanisms.
• Analyze and interpret data, present findings at scientific meetings, and publish results in peer‑reviewed journals.
• Collaborate with multidisciplinary teams and contribute to grant and manuscript preparation.
• Mentor students and trainees in a collaborative research environment.

• PhD, MD, or MD/PhD in Immunology, Hematology, Stem Cell Biology, Molecular Biology, Genetics, or a related field.
• Demonstrated research productivity and the ability to conduct independent scientific research.

• Strong background in immunology, hematology, stem cell biology, or a related biomedical discipline.
• Experience with mouse handling and in vivo experimentation.
• Experience with flow cytometry and immune cell phenotyping.
• Experience with standard molecular and cellular biology techniques.
• Ability to design and execute experiments, analyze data, and interpret results independently.
• Excellent written and oral communication skills, including scientific presentation and manuscript preparation.
• Strong organizational skills and the ability to work effectively both independently and as part of a collaborative team.
• Demonstrated commitment to scientific rigor, creativity, and problem‑solving.

• Experience in T cell biology, hematopoiesis, stem cell biology, or bone marrow microenvironment.
• Experience with genomic, single‑cell, or other high‑dimensional data analyses.
• Familiarity with CRISPR‑based genome engineering, transplantation models, or advanced immunological techniques.
• Experience with vaccine development, immunotherapy, or translational immunology.
• Interest in translational research related to hematologic disorders.

• A Blend of Academic Freedom and Industrial Efficiency:
  Access to shared resources and facilities led by expert scientists, coupled with cutting‑edge technology, accelerates research productivity.
• Customized Professional and Career Growth:
  Programs designed to enhance professional growth and career readiness, including grant writing workshops, individual development plans, teaching and mentoring opportunities, non‑research career advancement programs, professional development allowance, and more.
• Competitive Compensation:
  Salary starting at $72,500 a year, comprehensive benefits, and generous relocation assistance.
• A Sense of Community: A vibrant postdoc community that supports a well‑balanced life and promotes connections and camaraderie among postdocs from all backgrounds.

St. Jude is an Equal Opportunity Employer.

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. All resumes submitted by search firms without a valid written search agreement in place will result in no fee being paid in the event the candidate is hired by St. Jude.