Postdoctoral Research Associate - Hematology

Position

Postdoctoral research associate position in the Yamashita lab e Children’s Research Hospital.

Hematopoietic stem cells (HSCs) sustain lifelong blood production. Defects in HSC regulation contribute to hematologic disorders, including clonal hematopoiesis, hematologic malignancies, and aplastic anemia. The project examines how T‑cell–mediated immune surveillance regulates HSC fate in the bone marrow and influences disease outcomes. Using mouse models, flow cytometry, and single‑cell technologies, the candidate will investigate immune–stem cell interactions and identify therapeutic opportunities.

• Conduct independent research on T‑cell–mediated regulation of hematopoietic stem cells and bone marrow immunity.
• Design and perform experiments with mouse models, flow cytometry, molecular biology, and immunological approaches.
• Apply single‑cell and other advanced technologies to investigate immune‑stem cell interactions and disease mechanisms.
• Analyze and interpret data, present findings at scientific meetings, and publish results in peer‑reviewed journals.
• Collaborate with multidisciplinary teams and contribute to grant and manuscript preparation.
• Mentor students and trainees in a collaborative research environment.

PhD, MD, or MD/PhD in Immunology, Hematology, Stem Cell Biology, Molecular Biology, Genetics, or a related field and demonstrated research productivity.

• Strong background in immunology, hematology, stem cell biology, or a related biomedical discipline.
• Experience with mouse handling, in vivo experimentation, flow cytometry, and immune cell phenotyping.
• Proficiency in standard molecular and cellular biology techniques.
• Ability to design, execute, analyze, and interpret experiments independently.
• Excellent written and oral communication skills, including scientific presentation and manuscript preparation.
• Strong organizational skills and ability to work effectively both independently and as part of a collaborative team.
• Commitment to scientific rigor, creativity, and problem‑solving.

• Experience in T‑cell biology, hematopoiesis, or bone marrow microenvironment.
• Experience with genomic, single‑cell, or other high‑dimensional data analysis.
• Familiarity with CRISPR‑based genome engineering, transplantation models, or advanced immunological techniques.
• Experience with vaccine development, immunotherapy, or translational immunology.
• Interest in translational research related to hematologic disorders.

• Competitive salary starting at $72,500 per year.
• Comprehensive benefits and generous relocation assistance.

St. Jude is an Equal Opportunity Employer. St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms. No fee will be paid for candidates introduced by a search firm without a valid written agreement.