Scientist Antibody Discovery

Overview

Join an excellent team of researchers dedicated to advancing the mission of St. Jude Children's Research Hospital, ensuring that no child will die at the dawn of life. The Antibody Discovery Collaborative Centre (ADCC) within the Department of Host‑Microbe Interactions seeks a skilled and highly motivated candidate with experience in antibody discovery, protein engineering, or expression and validation of biologics.

• Antibody Discovery: Focus on display methods (phage, yeast, mammalian), build high‑diversity libraries from synthetic and animal repertoires, integrate machine‑learning approaches, design discovery workflows, and deliver panels of lead candidates.
• Apply in‑vitro display methods for sequence discovery and manage multiple screening arms for antigens; apply NGS methods to mine antibody pools for sequence discovery.
• Protein Science: Develop and optimize high‑throughput mammalian cell‑based production platforms for recombinant antibodies, antigens, and other biologics; support mAb discovery platforms in construct generation; perform DNA preparations for high‑quality plasmid material for mammalian cell transfection; establish scalable transient and stable expression workflows in CHO, HEK
  293, and other systems.
• Purify proteins using AKTA chromatography systems and perform HPLC‑SEC analysis of purified proteins.
• Conduct molecular assessment of early‑stage development candidates (polyreactivity ELISA, CE‑SDS, SEC‑MALS, DSF).
• Maintain accurate and timely ELN data.

• Experience merging cryo‑EM techniques with epitope analysis of antibody repertoires.
• Experience with high‑throughput automated protein purification systems (e.g., Kingfisher).
• Experience with antibody‑related bioinformatics and software packages.
• Expertise in high‑throughput molecular biology approaches for construct and library generation.
• Experience with mAb characterization techniques (FACS, BLI, epitope binning).

• Bachelor's degree in a relevant scientific area is required.

• Eight (8) years of relevant work experience is required.
• Six (6) years of relevant work experience is required with a Master's degree.
• Three (3) years of relevant work experience is required with a PhD.

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is providing a reasonable estimate of the compensation range for this role. The estimate is  86,320 -  154,960 per year for the position of Scientist, Antibody Discovery. The final salary will be based on skills, experience, training, licensure, certifications, and other business and organizational needs.

St. Jude is an Equal Opportunity Employer.